Automated Function Prediction (AFP 2014)

自动功能预测 (AFP 2014)

• 批准号: 8720395
• 负责人: Predrag Radivojac
• 金额: $ 0.5万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-22 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8720395
• 关键词: Advertising; Algorithms; Area; Automated Annotation; Berlin; Bioinformatics; Biomedical Research; Boston; Collaborations; Communities; Computational Biology; Computational Technique; Computing Methodologies; Databases; Disease; Education; Effectiveness; Ensure; European; Expert Systems; Fostering; Funding; Future; Germany; Goals; Group Meetings; Historically Black Colleges and Universities; Incentives; Institutes; International; Journals; Life; Massachusetts; Measures; Methodology; Methods; Molecular; Molecular Biology; Ontology; Organism; Participant; Postdoctoral Fellow; Proteins; Protocols documentation; Research; Research Peer Review; Research Personnel; Role; Scientist; Senior Scientist; Series; Societies; Students; SwissProt; Techniques; Travel; Universities; Woman; Work; cost; experience; functional genomics; insight; interest; meetings; minority trainee; protein function; protein structure prediction; public health relevance; research study; special interest group; symposium; theories

DESCRIPTION (provided by applicant): We propose to organize a meeting titled Automated Function Prediction in the Summer of 2014 (AFP 2014). The meeting will consist of two components, the first being a series of talks (invited and contributed) and discussion sections dedicated to protein function research, with an emphasis on the theory and practice of computational methods utilized in functional annotation. The second component will provide a large-scale assessment of computational methods through participation in the 2nd Critical Assessment of Functional Annotation (CAFA), an experiment inspired by a highly-regarded CASP assessment protocol for protein structure prediction. Understanding protein function is critical to understanding life at the molecular level. It also provides important insights into understanding disease since many conditions arise as a consequence of the loss, disruption or gain of protein function. However, the rapidly growing number of sequenced organisms poses a challenge for functional genomics projects because of the need to experimentally annotate known proteins. Therefore, protein function prediction research is important for biomedical research. AFP 2014 will stimulate discussion and the exchange of ideas/experience regarding functional ontologies, experiments leading to functional annotations, biocuration, methodologies for predicting function, and effectiveness of these algorithms. The AFP 2014 meeting will be associated with the 22nd annual international conference on Intelligent Systems for Molecular Biology (ISMB), the official conference of the International Society for Computational Biology (ISCB). ISMB 2014 will be held in Boston, Massachusetts, in July of 2014, with AFP 2014 as a Special Interest Group meeting. This will not only ensure wide participation from the ISCB community, but also reduce costs compared to a stand-alone meeting. By organizing the CAFA challenge, we aim to not only assess the current methodology for function prediction, but also provide incentive for investigators to develop new and more accurate techniques that are necessary for the continuous progress of the field. The organizers of the meeting will strongly encourage broad participation of senior and junior scientists (including post-docs and students) as well as diversity. Collaboration is established with Jackson State University. Funding is requested for travel allowances only.

描述（由申请人提供）：我们建议在2014年夏天组织一次题为自动功能预测的会议（AFP 2014）。会议将由两部分组成，第一部分是一系列演讲（邀请和贡献）和讨论部分，致力于蛋白质功能研究，重点是功能注释中使用的计算方法的理论和实践。第二部分将通过参与第二次功能注释关键评估（CAFA）对计算方法进行大规模评估，该实验受到高度重视的CASP蛋白质结构预测评估协议的启发。了解蛋白质功能对于在分子水平上了解生命至关重要。它还为理解疾病提供了重要的见解，因为许多疾病是由于蛋白质功能的丧失、破坏或获得而引起的。然而，快速增长的测序生物体数量对功能基因组学项目提出了挑战，因为需要通过实验注释已知蛋白质。因此，蛋白质功能预测研究对生物医学研究具有重要意义。AFP 2014将激发关于功能本体论、导致功能注释的实验、生物定位、预测功能的方法以及这些算法的有效性的讨论和想法/经验的交流。AFP 2014会议将与第22届分子生物学智能系统国际会议（ISMB），国际计算生物学学会（ISCB）的官方会议相关联。ISMB 2014将于2014年7月在马萨诸塞州波士顿举行，AFP 2014将作为特别兴趣小组会议。这不仅将确保国际空间通信理事会社区的广泛参与，而且与单独举行会议相比，还将减少费用。通过组织CAFA挑战赛，我们的目标不仅是评估当前的功能预测方法，而且还为研究人员提供激励，以开发该领域不断进步所必需的新的和更准确的技术。会议的组织者将大力鼓励高级和初级科学家（包括博士后和学生）的广泛参与以及多样性。与杰克逊州立大学建立了合作关系。只要求提供旅费津贴。