Modulation of food reward by ghrelin

胃饥饿素对食物奖励的调节

• 批准号: 341538-2012
• 负责人: Abizaid, Alfonso
• 金额: $ 2.26万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527345
• 关键词: Modulation; food; reward; ghrelin

This proposal is a continuation of a previously funded research program aimed at providing evidence that the stomach-derived hormone ghrelin targets brain regions important for the display of motivated behaviors. In addition, this proposal discusses experiments that will elucidate the potential mechanisms underlying the effects of ghrelin on reward circuits, and the potential role of brain derived ghrelin acting on the VTA to produce motivated behaviors. The results from the proposed studies will lead to a better understanding of the neurobiological effects of ghrelin on goal seeking behaviors, and behaviors associated with addictive substances like cocaine.

这项提议是先前资助的一项研究计划的延续，该计划旨在提供证据，证明胃源性激素ghrelin针对大脑区域，这些区域对动机行为的展示很重要。此外，该提案还讨论了一些实验，这些实验将阐明胃饥饿素对奖励回路影响的潜在机制，以及脑源性胃饥饿素作用于腹侧被盖区以产生动机性行为的潜在作用。拟议研究的结果将有助于更好地了解ghrelin对目标寻求行为的神经生物学影响，以及与可卡因等成瘾物质相关的行为。