Pushing the limits of biomedical optics endoscopy through the development of dedicated instrumentation

通过开发专用仪器突破生物医学光学内窥镜的极限

• 批准号: 341555-2013
• 负责人: Boudoux, Caroline
• 金额: $ 2.11万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527358
• 关键词: Pushing; limits; biomedical; optics; endoscopy

The past 25 years have witnessed the emergence of a wide array of novel medical imaging modalities exploiting the interaction between laser light and biological tissues. The techniques are now used in biology for observing tissues at architectural (using large field-of-view modalities such as optical coherence tomography), cellular (using confocal microscopy) or molecular (using fluorescence or nonlinear techniques) levels. Translation to the clinical world will allow clinicians to perform minimally invasive diagnoses. While biomedical optics techniques have a resolution and contrast unsurpassed by conventional medical imaging instruments (such as X rays, MRI, PET), their penetration depth is too shallow to perform visualization of internal organs without developing small and flexible instruments known as endoscopes. Additionally, while fluorescent agents may be added to study biological processes in small animals, very few are approved for use in humans. We must therefore rely mostly on endogeneous molecules (eg fluorophores naturally present in human tissues) to obtain specific contrast.

在过去的25年里，出现了一系列利用激光与生物组织之间相互作用的新型医学成像模式。这些技术现在被用于生物学中观察组织，在建筑（使用大视场模式，如光学相干断层扫描），细胞（使用共聚焦显微镜）或分子（使用荧光或非线性技术）水平。翻译到临床世界将允许临床医生进行微创诊断。虽然生物医学光学技术具有传统医学成像仪器（如X射线，MRI， PET）无法超越的分辨率和对比度，但它们的穿透深度太浅，无法实现内部器官的可视化，而不开发称为内窥镜的小而灵活的仪器。此外，虽然荧光剂可以用于研究小动物的生物过程，但很少有荧光剂被批准用于人类。因此，我们必须主要依靠内源性分子（如天然存在于人体组织中的荧光团）来获得特定的对比。