Molecular regulation of IL-27-mediated inflammatory responses in myeloid cells

骨髓细胞中 IL-27 介导的炎症反应的分子调节

• 批准号: 342168-2012
• 负责人: Gee, Katrina
• 金额: $ 2.91万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527593
• 关键词: Molecular; regulation; IL; 27; mediated

Inflammation is one of the ways that our body heals from injury or assault to the immune system. There are different cells in the human system that are responsible for directing the inflammatory response. A specific type of cell, termed a monocyte, is responsible for secreting small proteins called cytokines. Cytokines act as instant messengers of the immune system, alerting and sending other cells to the site of inflammation. These alerts can lead to inflammation; there are several specific cytokines that cause inflammation and there are also specific cytokines that stop inflammation. In order to prevent tissue damage by the inflammation, the inflammatory response needs to start and stop at the right time. In this study we will investigate how a particular cytokine, called interleukin-27 (IL-27), regulates inflammation using cells isolated from healthy people. By studying how IL- 27 regulates inflammation, we may be able to identify new targets for treatment of inflammatory disorders.

炎症是我们的身体从伤害或攻击免疫系统中愈合的方式之一。人体系统中有不同的细胞负责指导炎症反应。一种特殊类型的细胞，称为单核细胞，负责分泌称为细胞因子的小蛋白质。细胞因子充当免疫系统的即时信使，警告并将其他细胞发送到炎症部位。这些警报可能导致炎症;有几种特定的细胞因子引起炎症，也有特定的细胞因子阻止炎症。为了防止炎症引起的组织损伤，炎症反应需要在正确的时间开始和停止。在这项研究中，我们将研究一种特殊的细胞因子，称为白细胞介素-27（IL-27），如何使用从健康人中分离的细胞调节炎症。通过研究IL- 27如何调节炎症，我们可能能够确定治疗炎症性疾病的新靶点。