Innate immune responses and IL-27: novel regulatory mechanisms of TLR7 expression and signaling

先天免疫反应和 IL-27：TLR7 表达和信号传导的新调节机制

• 批准号: RGPIN-2017-04526
• 负责人: Gee, Katrina
• 金额: $ 2.48万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629587
• 关键词: Innate; immune; responses; IL; 27

Induction of innate immune responses is accomplished by specific cytokines which activate, recruit, and control differentiation of immune cells necessary for control of immune responses. Of the sentinel proteins found on innate immune cells, the Toll-like receptor (TLR) family of pattern recognition receptors binds to molecular patterns present on a variety of pathogens. One family member, TLR7, is responsible for recognizing single-stranded RNA, genetic information for many viruses. The molecular mechanisms induced by cytokines to control TLR7 expression and function during an innate immune response have not been fully elucidated.

先天性免疫应答的诱导通过特异性细胞因子来完成，所述细胞因子激活、募集和控制控制免疫应答所必需的免疫细胞的分化。在先天性免疫细胞上发现的哨兵蛋白中，模式识别受体的Toll样受体（TLR）家族与多种病原体上存在的分子模式结合。家族成员之一，TLR7，负责识别单链RNA，许多病毒的遗传信息。在先天免疫应答期间由细胞因子诱导以控制TLR7表达和功能的分子机制尚未完全阐明。