Cellular mechanisms implicated in the regulation of the group IVA phospholipase A2 and lipid mediators biosynthesis in activited cells

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Our research group focuses at defining the molecular mechanisms implicated in the regulation of the cPLA2alpha, a key protein involved in the formation of several bioactive lipids. More precisely, the cPLA2alpha releases important components of cell membranes that are further transformed into potent bioactive lipids. Too much of these lipids worsens inflammatory diseases like arthritis and asthma. Therefore, understanding how our body generates these lipids is very important in order to prevent their bad effect. In this proposal, we aim at understanding the mechanisms by which cyclic AMP prevents the activation of the cPLA2alpha in activated cells. Our experimental approach will allow us to decipher all the steps implicated in this effect of cyclic AMP both in vitro and in human cells. This work will not only provide key notions about how the activity of the cPLA2alpha is controlled in our body. It will also serve to train undergraduate and graduate students to become highly qualified scientists.