Non-invasive in-vivo magnetic resonance imaging of microvascular physiology

微血管生理学的无创体内磁共振成像

• 批准号: 355795-2012
• 负责人: Cheng, HaiLing
• 金额: $ 2.19万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527897
• 关键词: Non; invasive; vivo; magnetic; resonance

Measuring blood flow, vessel size, and other physiological properties of small blood vessels provides valuable information about the health of tissue and the nature of abnormal alterations. Modern medical imaging techniques such as magnetic resonance imaging (MRI) provide a non-invasive way to measure these properties, but they all require the injection of contrast agents. This requirement precludes repeated measurements and is not accessible to very young children and other sensitive subjects. In this proposal, we develop a truly non-invasive MRI platform to measure small vessel structure and function with fine spatial detail - without injecting contrast. This is a novel and transformative technology that will greatly expand the scope of basic and applied research related to small blood vessels.

测量小血管的血流量、血管尺寸和其他生理特性可以提供有关组织健康和异常改变性质的宝贵信息。磁共振成像（MRI）等现代医学成像技术提供了一种非侵入性的方法来测量这些特性，但它们都需要注射造影剂。这一要求排除了重复测量，并且对于年幼的儿童和其他敏感对象来说是无法进行的。在这项提案中，我们开发了一个真正的非侵入性 MRI 平台，可以测量小血管的结构和功能，并具有精细的空间细节 - 无需注入造影剂。这是一项新颖的、革命性的技术，将极大地扩大与小血管相关的基础和应用研究的范围。