Quantitative measurement of microvascular physiology using dynamic contrast-enhanced magnetic resonance imaging

使用动态对比增强磁共振成像定量测量微血管生理学

• 批准号: 355795-2008
• 负责人: Cheng, HaiLing
• 金额: $ 1.46万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=482866
• 关键词: Quantitative; measurement; microvascular; physiology; using

Many biomedical imaging applications would greatly benefit from the ability to measure blood vessel function by analysing signal enhancement associated with tissue uptake of an injected contrast agent. Two specific examples from our ongoing research program in magnetic resonance imaging (MRI) include: (1) assessment of vessel development in cancer and their response to therapy, and (2) monitoring the growth of blood vessels in engineered or regenerated tissue, which is needed to promote and maintain cell growth. While the focus is geared towards improving health care, these clinical applications rely on appropriate mathematical modeling and signal processing techniques to extract accurate physiological information.

许多生物医学成像应用将大大受益于通过分析与注射造影剂的组织摄取相关的信号增强来测量血管功能的能力。我们正在进行的磁共振成像(MRI)研究计划中的两个具体例子包括：(1)评估癌症中的血管发育及其对治疗的反应，以及(2)监测工程组织或再生组织中血管的生长，这是促进和维持细胞生长所必需的。虽然重点是改善医疗保健，但这些临床应用依赖于适当的数学建模和信号处理技术来提取准确的生理信息。