Molecular Mechanisms Controlling Adhesion Dynamics During Cell Migration

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Cell migration is central to many fundamental biological processes such as tissue organization, neural development, wound healing and the immune response. Much that is known about cell migration has been learned from biochemical assays on cellular components and global measurements on cellular dynamics and migration speeds. However, to date the molecular mechanisms that regulate cell migration are not well understood. The main reason for this is that there has been a general lack of technologies readily available for researchers to study molecular dynamics and interactions within living cells. My research program focuses on the development and application of advance light microscopy technologies that can measure molecular dynamics and interactions in intact, living, migrating cells.