Molecular Mechanisms Controlling Adhesion Dynamics During Cell Migration

细胞迁移过程中控制粘附动力学的分子机制

• 批准号: 386084-2012
• 负责人: Brown, ClaireMarie
• 金额: $ 2.48万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528731
• 关键词: Molecular; Mechanisms; Controlling; Adhesion; Dynamics

Cell migration is central to many fundamental biological processes such as tissue organization, neural development, wound healing and the immune response. Much that is known about cell migration has been learned from biochemical assays on cellular components and global measurements on cellular dynamics and migration speeds. However, to date the molecular mechanisms that regulate cell migration are not well understood. The main reason for this is that there has been a general lack of technologies readily available for researchers to study molecular dynamics and interactions within living cells. My research program focuses on the development and application of advance light microscopy technologies that can measure molecular dynamics and interactions in intact, living, migrating cells.

细胞迁移是许多基本生物过程的核心，如组织组织、神经发育、伤口愈合和免疫反应。关于细胞迁移的许多知识已经从对细胞成分的生化分析以及对细胞动力学和迁移速度的全球测量中了解到。然而，到目前为止，调控细胞迁移的分子机制还不是很清楚。其主要原因是，研究人员普遍缺乏现成的技术来研究活细胞内的分子动力学和相互作用。我的研究计划专注于先进光学显微镜技术的开发和应用，这些技术可以测量完整的、活的、迁移的细胞中的分子动力学和相互作用。