Molecular mechanisms of endocrine disruption along the reproductive axis in fish

鱼类生殖轴内分泌干扰的分子机制

• 批准号: 386275-2010
• 负责人: Martyniuk, Christopher
• 金额: $ 2.7万
• 依托单位: University of New Brunswick
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528799
• 关键词: Molecular; mechanisms; endocrine; disruption; along

The major objective of this research program is to obtain a mechanistic understanding of how sex steroids (estrogens and androgens) mediate reproduction in fish and how these processes are affected by aquatic contaminants found in our environment. By characterizing molecular signaling cascades along the brain-pituitary-gonad-liver or reproductive axis, we will be able to develop molecular fingerprints or biomarkers which are useful in predicting adverse affects in wildlife health. This is important because many pesticides and herbicides used for agricultural practices in the Atlantic Provinces and throughout Canada enter water systems via runoff, acting as endocrine disrupting chemicals and negatively impact fish populations.

本研究项目的主要目的是获得性类固醇（雌激素和雄激素）如何调节鱼类繁殖的机制，以及这些过程如何受到我们环境中发现的水生污染物的影响。通过表征沿脑-垂体-性腺-肝脏或生殖轴的分子信号级联，我们将能够开发分子指纹或生物标志物，用于预测野生动物健康的不利影响。这一点很重要，因为大西洋各省和加拿大各地用于农业生产的许多农药和除草剂通过径流进入水系，作为内分泌干扰化学品，对鱼类种群产生负面影响。