Decoding the mammalian regulatory genome

点击翻译按钮获取中文摘要

Despite completion of the human genome sequence 16 years ago we are currently not able to determine the function of the vast majority of this sequence. We understand how to read the sequence code within gene coding regions but these are We will address three key questions: 1) Why are so many transcription factor binding sites needed for enhancer activity? 2) How is the regulatory code different in different cell types? 3) What is the best computational approach to fully decode mammalian genomes? In the long term fully decoding genome sequences will allow us to predict how regulatory sequence changes will affect the expression of specific genes. This will have widespread impact on our understanding of development, evolution and the underlying cause of phenotype variation in populations.