Aberrant Palmitoylation in the Pathogenesis of Huntington Disease

亨廷顿病发病机制中的异常棕榈酰化

• 批准号: 277762
• 负责人: Schmidt Mandi E
• 金额: $ 1.27万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-02-01 至 2014-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=277762&lang=en
• 关键词: Animal Cell Culture; Huntingtin Protein Interactions; Huntington Disease; Microscopy; Palmitoylation; Post-Translational Modification; Protein Purification And Enzyme Assays; Therapeutic Targets

Huntington disease (HD) is a devastating neurodegenerative condition which causes death of the striatal neurons in the brain, leading to cognitive, psychiatric and motor coordination decline during mid-life. The disease is caused by a genetic mutation in

亨廷顿病（HD）是一种破坏性的神经退行性疾病，其导致大脑中纹状体神经元的死亡，导致中年期间认知、精神和运动协调性下降。这种疾病是由基因突变引起的，