Dynamical Regulation in Physiological Systems

生理系统的动态调节

• 批准号: 8806-2012
• 负责人: Bélair, Jacques
• 金额: $ 1.82万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=544554
• 关键词: Dynamical; Regulation; Physiological; Systems

Many physiological phenomena show complex fluctuations. This variability can be an index of the health of the individual, as in the case of the heart rate, fluctuations in sleep-wake cycle or smooth muscle contractions in the gastro-intestinal track. In recent years, research combining experimental studies of physiological systems with theoretical models of physiological dynamics has provided new insight into the mechanisms responsible for some cardiac and hematological disorders. Carrying out the appropriate experiments requires great care and precision in order to obtain data sufficiently detailed to be compared with theoretical observations which in turn suggest new theoretical (modeling) approaches.

许多生理现象表现出复杂的波动。这种可变性可以作为个体健康状况的指标，比如心率、睡眠-觉醒周期波动或胃肠道平滑肌收缩。近年来，将生理系统实验研究与生理动力学理论模型相结合的研究为一些心脏和血液系统疾病的机制提供了新的认识。进行适当的实验需要非常小心和精确，以便获得足够详细的数据，以便与理论观察进行比较，而理论观察反过来又提出新的理论（建模）方法。