Dynamical Regulation in Physiological Systems

生理系统的动态调节

• 批准号: RGPIN-2018-05869
• 负责人: Bélair, Jacques
• 金额: $ 1.31万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=645005
• 关键词: Dynamical; Regulation; Physiological; Systems

Many physiological phenomena show complex fluctuations. This variability can be an index of the***health of the individual, as in the case of the heart rate, fluctuations in sleep-wake cycle or smooth muscle***contractions in the gastro-intestinal track. In recent years, research combining experimental studies of***physiological systems with theoretical models of physiological dynamics has provided new insight into the mechanisms responsible for some cardiac and hematological disorders. Carrying out the appropriate experiments requires***great care and precision in order to obtain data sufficiently detailed to be compared with theoretical observations***which in turn suggest new theoretical (modeling) approaches.***For the following systems, we will be developing mathematical models thriving for a***representation that is simplified enough to allow for significant understanding of the system as a***whole, yet is complex enough to incorporate all the fundamental components of the physiology.***1) The regulation of the circulating blood cells is a complex biochemical system. We study the***influence of the main regulatory protein, erythropoietin (EPO), in the feedback mechanism maintaining the number of red blood cells (which carry oxygen to all tissues and organs) at an appropriate level; we also explore the interactions of these cells with systems predominantly controlling the regulation of the other types of circulating blood cells (mainly platelets, which are responsible for the prevention of bleeding).***2) Emerging zoonotic diseases are defined by the World Health Organization (WHO) as diseases transmitted from animals to men "that are newly recognized or newly evolved, or that have occurred previously but show an increase in incidence or expansion in geographical, host or vector range". With modifications in the habitat of a number of species involved in the transmission of these diseases, there is renewed interest in understanding their propagation mechanisms. We shall investigate mathematical models for such a mosquito-borne disease, Dengue Fever (DF), trying to understand the dynamics of multiple expositions to different strains of DF.

许多生理现象表现出复杂的波动。这种变异性可以是个体健康的指数，如心率、睡眠-觉醒周期的波动或胃肠道中的平滑肌收缩。近年来，结合生理系统的实验研究和生理动力学的理论模型的研究为一些心脏和血液疾病的机制提供了新的见解。进行适当的实验需要非常小心和精确，以获得足够详细的数据，以便与理论观察进行比较，从而提出新的理论（建模）方法。对于下面的系统，我们将开发数学模型，以实现一种 * 的表示，这种表示足够简化，以允许对系统作为一个 * 整体的重要理解，但又足够复杂，以包含生理学的所有基本组成部分。1)循环血细胞的调节是一个复杂的生化系统。我们研究了主要调节蛋白促红细胞生成素（EPO）在维持红细胞数量的反馈机制中的影响（将氧气输送到所有组织和器官）;我们还探索了这些细胞与主要控制其他类型循环血细胞调节的系统的相互作用（主要是血小板，负责预防出血）。* 2)世界卫生组织（世卫组织）将新出现的人畜共患疾病定义为“新近发现或新近演变的，或以前发生过但发病率增加或地理、宿主或病媒范围扩大”的从动物传播给人的疾病。随着参与这些疾病传播的一些物种的栖息地发生变化，人们对了解其传播机制重新产生了兴趣。我们将研究这种蚊媒疾病登革热（DF）的数学模型，试图了解不同DF菌株的多次暴露的动力学。