Dynamical Regulation in Physiological Systems

生理系统的动态调节

• 批准号: RGPIN-2018-05869
• 负责人: Bélair, Jacques
• 金额: $ 2.62万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=759363
• 关键词: Dynamical; Regulation; Physiological; Systems

Many physiological phenomena show complex fluctuations. This variability can be an index of thehealth of the individual, as in the case of the heart rate, fluctuations in sleep-wake cycle or smooth musclecontractions in the gastro-intestinal track. In recent years, research combining experimental studies ofphysiological systems with theoretical models of physiological dynamics has provided new insight into the mechanisms responsible for some cardiac and hematological disorders. Carrying out the appropriate experiments requiresgreat care and precision in order to obtain data sufficiently detailed to be compared with theoretical observationswhich in turn suggest new theoretical (modeling) approaches.For the following systems, we will be developing mathematical models thriving for arepresentation that is simplified enough to allow for significant understanding of the system as awhole, yet is complex enough to incorporate all the fundamental components of the physiology.1) The regulation of the circulating blood cells is a complex biochemical system. We study theinfluence of the main regulatory protein, erythropoietin (EPO), in the feedback mechanism maintaining the number of red blood cells (which carry oxygen to all tissues and organs) at an appropriate level; we also explore the interactions of these cells with systems predominantly controlling the regulation of the other types of circulating blood cells (mainly platelets, which are responsible for the prevention of bleeding).2) Emerging zoonotic diseases are defined by the World Health Organization (WHO) as diseases transmitted from animals to men "that are newly recognized or newly evolved, or that have occurred previously but show an increase in incidence or expansion in geographical, host or vector range". With modifications in the habitat of a number of species involved in the transmission of these diseases, there is renewed interest in understanding their propagation mechanisms. We shall investigate mathematical models for such a mosquito-borne disease, Dengue Fever (DF), trying to understand the dynamics of multiple expositions to different strains of DF.

许多生理现象都表现出复杂的波动。这种变异性可以作为个体健康的指标，例如心率、睡眠-清醒周期的波动或胃肠道轨迹的平滑肌肉收缩。近年来，将生理系统的实验研究与生理动力学的理论模型相结合的研究为一些心脏和血液疾病的发病机制提供了新的见解。进行适当的实验需要非常仔细和精确，以便获得足够详细的数据，以便与理论观察进行比较，理论观察反过来又提出了新的理论(建模)方法。对于以下系统，我们将开发数学模型，以便于对系统整体的显著了解，但又足够复杂，可以纳入生理学的所有基本组成部分。1)循环血细胞的调节是一个复杂的生化系统。我们研究主要调节蛋白促红细胞生成素(EPO)在反馈机制中的影响，将红细胞(将氧气输送到所有组织和器官)的数量维持在适当水平；我们还探索这些细胞与主要控制其他类型的循环血细胞(主要是负责防止出血的血小板)的系统的相互作用。2)新出现的人畜共患疾病被世界卫生组织(WHO)定义为从动物传播给人类的疾病“是新发现的或新进化的，或以前发生过但发病率增加或地理、宿主或媒介范围扩大的疾病”。随着参与这些疾病传播的一些物种栖息地的改变，人们对了解它们的传播机制重新产生了兴趣。我们将研究这样一种蚊媒疾病--登革热(DF)的数学模型，试图了解不同菌株登革热的多重暴露的动态。