Neural responses to abiotic stress in locusts
蝗虫对非生物胁迫的神经反应
基本信息
- 批准号:40930-2009
- 负责人:
- 金额:$ 4.37万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2014
- 资助国家:加拿大
- 起止时间:2014-01-01 至 2015-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Variation in environmental conditions, such as ambient temperature and oxygen levels, can have dramatic consequences for the operation of the nervous system, which thus endangers animals. For those animals that actively negotiate their environments this occurs at the point when vital neuronal circuits are impaired, long before cells and tissues suffer direct damage. For example, even marginally impaired operation of the neural circuitry for detecting the rapidly looming approach of predators will increase the risk that an organism fails to escape capture and consumption. Also it is important to ensure that the neural circuit responsible for providing working muscles with an adequate oxygen supply continues to operate effectively. My research program is concerned with discovering the mechanisms by which nervous systems fail under extreme conditions and those that allow some animals to continue behaving in the same environment. We use the African migratory locust as a model system for our studies because these animals are regularly exposed to high temperatures and, in different seasons, the risk of flooding and immersion. Locusts, and most other insects, have the ability to survive stressful times by entering a coma during which energy is conserved and from which recovery is apparently complete. Over the next five years we will describe some of the pathways and processes by which this is achieved and investigate how nervous system function is modified for more efficient operation after recovering from the coma. One idea of general interest to all neuroscientists is that nervous systems are tuned for optimal performance in a process whereby there is a continuous trade-off between high performance and energy conservation. Also the neural shutdown during the coma is very similar to the processes underlying dysfunctions of the mammalian nervous system including stroke and migraine. Understanding how neural tissue copes with stress is important at the level of operation but also in consideration of how populations might be affected by climate change; particularly important for pest species such as locusts and grasshoppers.
环境条件的变化,如环境温度和氧气水平,会对神经系统的运作产生严重影响,从而危及动物。 对于那些积极适应环境的动物来说,这发生在重要的神经回路受损的时候,远在细胞和组织遭受直接损伤之前。例如,即使是轻微受损的神经回路的运作,以检测迅速逼近的捕食者将增加风险,一个有机体未能逃脱捕获和消费。 此外,重要的是要确保负责为工作肌肉提供足够氧气供应的神经回路继续有效地运作。 我的研究计划是关于发现神经系统在极端条件下失败的机制,以及那些允许一些动物在相同环境中继续行为的机制。 我们使用非洲飞蝗作为我们研究的模型系统,因为这些动物经常暴露在高温下,在不同的季节,有洪水和浸泡的风险。 蝗虫和大多数其他昆虫都有能力在压力下生存,它们会进入昏迷状态,在昏迷状态下,能量被保存下来,而且显然可以完全恢复。 在接下来的五年里,我们将描述一些实现这一目标的途径和过程,并研究如何在从昏迷中恢复后修改神经系统功能以实现更有效的操作。 所有神经科学家普遍感兴趣的一个想法是,神经系统在一个过程中被调整为最佳性能,在这个过程中,在高性能和节能之间存在持续的权衡。 此外,昏迷期间的神经关闭与哺乳动物神经系统功能障碍(包括中风和偏头痛)的潜在过程非常相似。 了解神经组织如何应对压力在操作层面很重要,但在考虑种群如何受到气候变化的影响时也很重要;对于蝗虫和蚱蜢等害虫物种尤其重要。
项目成果
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Robertson, Meldrum其他文献
Robertson, Meldrum的其他文献
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{{ truncateString('Robertson, Meldrum', 18)}}的其他基金
Neural responses to abiotic stress in locusts
蝗虫对非生物胁迫的神经反应
- 批准号:
40930-2009 - 财政年份:2016
- 资助金额:
$ 4.37万 - 项目类别:
Discovery Grants Program - Individual
Neural responses to abiotic stress in locusts
蝗虫对非生物胁迫的神经反应
- 批准号:
40930-2009 - 财政年份:2015
- 资助金额:
$ 4.37万 - 项目类别:
Discovery Grants Program - Individual
Neural responses to abiotic stress in locusts
蝗虫对非生物胁迫的神经反应
- 批准号:
40930-2009 - 财政年份:2013
- 资助金额:
$ 4.37万 - 项目类别:
Discovery Grants Program - Individual
Neural responses to abiotic stress in locusts
蝗虫对非生物胁迫的神经反应
- 批准号:
40930-2009 - 财政年份:2012
- 资助金额:
$ 4.37万 - 项目类别:
Discovery Grants Program - Individual
Neural responses to abiotic stress in locusts
蝗虫对非生物胁迫的神经反应
- 批准号:
40930-2009 - 财政年份:2011
- 资助金额:
$ 4.37万 - 项目类别:
Discovery Grants Program - Individual
Neural responses to abiotic stress in locusts
蝗虫对非生物胁迫的神经反应
- 批准号:
40930-2009 - 财政年份:2010
- 资助金额:
$ 4.37万 - 项目类别:
Discovery Grants Program - Individual
Neural responses to abiotic stress in locusts
蝗虫对非生物胁迫的神经反应
- 批准号:
40930-2009 - 财政年份:2009
- 资助金额:
$ 4.37万 - 项目类别:
Discovery Grants Program - Individual
Neuroecology of locust behaviour
蝗虫行为的神经生态学
- 批准号:
40930-2004 - 财政年份:2008
- 资助金额:
$ 4.37万 - 项目类别:
Discovery Grants Program - Individual
Neuroecology of locust behaviour
蝗虫行为的神经生态学
- 批准号:
40930-2004 - 财政年份:2007
- 资助金额:
$ 4.37万 - 项目类别:
Discovery Grants Program - Individual
Measurement of extracellular potassium dynamics
细胞外钾动力学的测量
- 批准号:
346278-2007 - 财政年份:2006
- 资助金额:
$ 4.37万 - 项目类别:
Research Tools and Instruments - Category 1 (<$150,000)
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