Plasmids and virulence in animal disease isolates of type A Clostridium perfringens

A 型产气荚膜梭菌动物疾病分离株的质粒和毒力

• 批准号: 183796-2011
• 负责人: Prescott, John
• 金额: $ 2.91万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=545952
• 关键词: Plasmids; virulence; animal; disease; isolates

There are a number of very important but not-well-characterized intestinal diseases of different animal species associated with the bacterium Clostridium perfringens, which are responsible for serious and often fatal illness. These range from commonly fatal diseases such as haemorrhagic abomasitis of cattle and typhlocolitis of horses, to less severe diseases such as neonatal enteritis of swine. The lack of characterization of these diseases rests on the uncertainty about the role of C. perfringens, and therefore uncertainties about diagnosis and control. It also leads to non-targeted use of antibiotics and thus potentially enhances antibiotic resistance.

在不同的动物物种中，有许多非常重要但特征不明确的肠道疾病与产气荚膜梭状芽胞杆菌有关，这种细菌会导致严重甚至致命的疾病。这些疾病的范围从通常致命的疾病，如牛的出血性胃炎和马的伤寒结肠炎，到不太严重的疾病，如猪的新生儿肠炎。由于对产气荚膜原梭菌的作用不确定，因此对这些疾病的诊断和控制也不确定，因此缺乏对这些疾病的特征描述。它还导致抗生素的非靶向使用，从而可能增强抗生素耐药性。