Identification of candidate components of a novel Bordetella avium vaccine to prevent turkey coryza

禽博德氏菌感染火鸡的呼吸道，引起火鸡鼻炎，其主要特征是鼻分泌物。这种疾病通常与受感染禽鸟体重增加不足有关。在大多数情况下，禽类会在两到四周内清除感染。然而，鸟芽胞杆菌感染的一个重要并发症是对鸟类呼吸道的损害，使其更容易受到其他继发性感染。因此，鸟芽胞杆菌感染不仅会导致火鸡鼻炎，还会增加其他更严重感染的发生率。目前用于防止火鸡感染鸟芽胞杆菌的疫苗效果不佳，而且含有特征不佳的减毒菌株。现代疫苗学已经取得了很大的进步，远远超出了使用这种知之甚少的菌株作为疫苗的过程。合理的疫苗设计，特别是使用纯化的细菌成分来配制非细胞疫苗，是生产有效疫苗以预防感染的更成功的方法。该项目将确定鸟芽杆菌的组成部分，参与其定植和破坏火鸡呼吸道的能力，作为开发一种新的有效疫苗的起点，以保护火鸡免受鸟芽杆菌感染。消除或显著减少商业火鸡群中的鸟b族感染将有助于减轻火鸡生产者所承受的疾病负担。该行业是加拿大经济活动的重要来源，改进火鸡生产工艺将为该行业和加拿大带来显著的经济效益。

The bacterium Bordetella avium infects the respiratory tract of turkeys to cause turkey coryza that is mainly characterised by nasal discharge. This disease is often associated with poor weight gain of affected birds. In most cases the bird will clear the infection within two to four weeks. However, an important complication of B. avium infection is damage to the bird's respiratory tract that renders it more susceptible to other secondary infections. Thus, B. avium infection not only leads to turkey coryza but also to an increased incidence of other, more serious infections. Current vaccines to prevent B. avium infection of turkeys do not work well and comprise poorly characterised attenuated strains of the bacterium. Modern vaccinology has progressed well beyond the process of using such poorly understood strains as vaccines. Rational vaccine design, particularly using purified components of bacteria to formulate an acellular vaccine, is a far more successful approach to producing effective vaccines to prevent infection. This project will identify the B. avium components involved in its ability to colonise and damage the turkey respiratory tract as the starting point to developing a novel and effective vaccine to protect turkeys against B. avium infection. Eliminating or significantly decreasing B. avium infections among commercial turkey flocks will help to reduce the burden of disease endured by turkey producers. This industry is an important source of economic activity in Canada and improvements to turkey production processes will result in significant economic benefits to the industry and to Canada.