Molecular analyses of the iron starvation response in the coagulase-negative group of staphylococci
葡萄球菌凝固酶阴性组铁饥饿反应的分子分析
基本信息
- 批准号:227295-2011
- 负责人:
- 金额:$ 2.91万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2014
- 资助国家:加拿大
- 起止时间:2014-01-01 至 2015-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Iron is required by all life forms, yet it's very low availability frequently make it a growth-limiting nutrient. This presents significant problems to all life forms which must therefore find innovative ways to gain access to this nutrient in order to survive. This is no less true for bacteria. Many bacteria emit what are called siderophores into the surrounding environment to bind iron and deliver iron back to the bacterial cell. Many bacteria that are found in association with humans and animals can also capture iron out of hemoglobin as a way to support their own survival. A group of bacteria called coagulase-negative staphylococci are typically referred to as commensals, that is, they live in close association with animals and humans and do not cause disease but rather promote health. Indeed, experts estimate that there are actually 10 times as many bacteria found in and on mammals than there are mammalian cells. For coagulase-negative staphylococci, their very presence on skin and mucous membranes actually helps defend against infection by disease-causing bacteria. This research will identify the ways in which these bacteria access iron as a means to survive and and grow. With our NSERC-funded history of characterizing iron acquisition systems in the highly infectious Staph aureus bacterium, the research to be undertaken on the commensal bacteria over the next five years will provide us with a fundamental understanding of similarities and differences in iron acquisition systems in major disease-causing bacteria versus important commensal bacteria that are much less likely to cause infection. This research will inform us about the possibilities of whether antibacterials that might target iron acquisition processes in the disease-causing bacteria will have collateral effects on commensal bacteria.
铁是所有生命形式所必需的,但它的可利用性很低,经常使其成为限制生长的营养物质。这给所有生命形式带来了重大问题,因此它们必须找到创新的方式来获得这种养分以求生存。细菌也是如此。许多细菌向周围环境释放所谓的铁载体,以结合铁并将铁输送回细菌细胞。许多被发现与人类和动物有关的细菌也可以从血红蛋白中捕获铁来支持自己的生存。一组被称为凝固酶阴性葡萄球菌的细菌通常被称为共生体,即它们与动物和人类密切相关,不会导致疾病,而是促进健康。事实上,专家估计,实际上在哺乳动物体内和身上发现的细菌数量是哺乳动物细胞数量的10倍。对于凝固酶阴性的葡萄球菌,它们在皮肤和粘膜上的存在实际上有助于抵御致病细菌的感染。这项研究将确定这些细菌获取铁作为生存和生长手段的方式。凭借我们由NSERC资助的描述高传染性金黄色葡萄球菌中铁获取系统的历史,未来五年将对共生细菌进行的研究将使我们从根本上了解主要致病细菌与不太可能导致感染的重要共生细菌中铁获取系统的异同。这项研究将告诉我们,可能针对致病细菌中铁获取过程的抗菌药是否会对共生细菌产生附带影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Heinrichs, David其他文献
Heinrichs, David的其他文献
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{{ truncateString('Heinrichs, David', 18)}}的其他基金
Interactions between coagulase-negative staphylococci and the host
凝固酶阴性葡萄球菌与宿主之间的相互作用
- 批准号:
RGPIN-2022-04699 - 财政年份:2022
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Characterization of molecular mechanisms of resistance to antimicrobial fatty acids in the staphylococci
葡萄球菌抗微生物脂肪酸分子机制的表征
- 批准号:
RGPIN-2016-05047 - 财政年份:2021
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Characterization of molecular mechanisms of resistance to antimicrobial fatty acids in the staphylococci
葡萄球菌抗微生物脂肪酸分子机制的表征
- 批准号:
RGPIN-2016-05047 - 财政年份:2020
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Characterization of molecular mechanisms of resistance to antimicrobial fatty acids in the staphylococci
葡萄球菌抗微生物脂肪酸分子机制的表征
- 批准号:
RGPIN-2016-05047 - 财政年份:2019
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Characterization of molecular mechanisms of resistance to antimicrobial fatty acids in the staphylococci
葡萄球菌抗微生物脂肪酸分子机制的表征
- 批准号:
RGPIN-2016-05047 - 财政年份:2018
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Characterization of molecular mechanisms of resistance to antimicrobial fatty acids in the staphylococci
葡萄球菌抗微生物脂肪酸分子机制的表征
- 批准号:
RGPIN-2016-05047 - 财政年份:2017
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Characterization of molecular mechanisms of resistance to antimicrobial fatty acids in the staphylococci
葡萄球菌抗微生物脂肪酸分子机制的表征
- 批准号:
RGPIN-2016-05047 - 财政年份:2016
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Molecular analyses of the iron starvation response in the coagulase-negative group of staphylococci
葡萄球菌凝固酶阴性组铁饥饿反应的分子分析
- 批准号:
227295-2011 - 财政年份:2015
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Examination of AcpS in the survival of S. aureus
AcpS 在金黄色葡萄球菌存活中的检测
- 批准号:
470317-2014 - 财政年份:2014
- 资助金额:
$ 2.91万 - 项目类别:
Engage Grants Program
Molecular analyses of the iron starvation response in the coagulase-negative group of staphylococci
葡萄球菌凝固酶阴性组铁饥饿反应的分子分析
- 批准号:
227295-2011 - 财政年份:2013
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
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Molecular analyses of the iron starvation response in the coagulase-negative group of staphylococci
葡萄球菌凝固酶阴性组铁饥饿反应的分子分析
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Molecular analyses of the iron starvation response in the coagulase-negative group of staphylococci
葡萄球菌凝固酶阴性组铁饥饿反应的分子分析
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227295-2011 - 财政年份:2013
- 资助金额:
$ 2.91万 - 项目类别:
Discovery Grants Program - Individual
Molecular analyses of the iron starvation response in the coagulase-negative group of staphylococci
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Discovery Grants Program - Individual
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葡萄球菌凝固酶阴性组铁饥饿反应的分子分析
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