Surface Processing of Orthopaedic Implants for Controlled Drug Delivery and Enhanced Bone Integration

用于控制药物输送和增强骨整合的骨科植入物的表面处理

• 批准号: 249524-2012
• 负责人: Wang, Rizhi
• 金额: $ 2.11万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=547305
• 关键词: Surface; Processing; Orthopaedic; Implants; Controlled

The application of artificial joints such as total hip implants has greatly improved the quality of life of many people suffering from osteoarthritis and osteoporosis. With an aging population the demands for such devices will constantly rise. Although fairly reliable, current total hip arthroplasty is facing two critical and surface-related challenges that impair its longevity: the peri-implant infection, and the emerging issue of early implant failure due to inadequate bone growth and adverse tissue responses. Solutions to prevent or treat implant related infections are further complicated by the concern over the development of antibiotic resistance.

全髋关节植入物等人工关节的应用，极大地改善了许多骨关节炎和骨质疏松症患者的生活质量。 随着人口老龄化，对此类设备的需求将不断增加。虽然相当可靠，目前的全髋关节置换术正面临着两个关键的和表面相关的挑战，损害其寿命：植入物周围感染，以及由于骨生长不足和不良组织反应导致的早期植入物失效的新问题。 预防或治疗植入物相关感染的解决方案由于对抗生素耐药性发展的担忧而进一步复杂化。