Processing of calcium phosphate – functional peptide composites for orthopaedic applications

用于骨科应用的磷酸钙 – 功能性肽复合材料的加工

• 批准号: RGPIN-2017-04931
• 负责人: Wang, Rizhi
• 金额: $ 2.4万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638086
• 关键词: Processing; calcium; phosphate; functional; peptide

With an aging population, there are increasing demands for biomaterials and biomedical devices to replace or restore tissue functions. In orthopaedics alone, more than 100,000 artificial hip and knee joints in Canada are implanted every year. Prosthetic joint infections are major complications in orthopaedic surgery. The overall infection rate is 0.5-5% for joint replacement surgery and infection also accounts for about 18% of the total implant failure. Implant infection brings severe consequences to the patients and the health care system, including substantially prolonged hospitalization, increased number of revision surgery, significant increase in healthcare costs, and increased mortality rate. Local delivery of traditional antibiotics could prevent bacteria adhesion and peri-implant infection. However, a serious concern over using traditional antibiotics such as vancomycin for local delivery is the development and spreading of antibiotic resistant pathogens. Such antibiotic resistance can lead to devastating effects and has become a serious public health problem.

随着人口老龄化，对生物材料和生物医学装置的需求越来越大，以替代或恢复组织功能。仅在矫形外科，加拿大每年就有10万多个人工髋关节和膝关节被植入。人工关节感染是骨科手术的主要并发症。关节置换手术的总体感染率为0.5-5%，感染也占植入物总失效的约18%。植入物感染给患者和医疗保健系统带来严重后果，包括住院时间延长、翻修手术次数增加、医疗保健成本显著增加和死亡率增加。传统抗生素局部应用可预防细菌粘附和种植体周围感染。然而，使用传统抗生素如万古霉素进行局部递送的严重问题是抗生素抗性病原体的发展和传播。这种抗生素耐药性可能导致毁灭性的影响，并已成为一个严重的公共卫生问题。