Understanding innate immune responses of insect vectors to intracellular pathogens.

了解昆虫载体对细胞内病原体的先天免疫反应。

• 批准号: 261940-2013
• 负责人: Lowenberger, Carl
• 金额: $ 4.23万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=547920
• 关键词: Understanding; innate; immune; responses; insect

This proposal will address the molecular interactions between Aedes aegypti, the insect vector of Dengue viruses (DENv) to humans. Specifically we will look at the immune immune processes used by mosquitoes to eliminate DENv, and how the viruses circumvent these responses. Recent studies have addressed the role of molecules and pathways that regulate or determine the intracellular development of DENv in mosquitoes, but the majority of these studies have used lab strains of mosquitoes that are susceptible to DENv.

该提案将解决埃及伊蚊（人类登革热病毒（DENv）的昆虫载体）之间的分子相互作用。具体来说，我们将研究蚊子用来消除 DENv 的免疫过程，以及病毒如何规避这些反应。最近的研究已经探讨了调节或决定蚊子中 DENv 细胞内发育的分子和途径的作用，但这些研究中的大多数都使用了对 DENv 敏感的实验室蚊子品系。