Microsystems for drug discovery and biological studies

用于药物发现和生物学研究的微系统

• 批准号: 327592-2010
• 负责人: Selvaganapathy, Ponnambalam
• 金额: $ 3.13万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=549133
• 关键词: Microsystems; drug; discovery; biological; studies

Microfabricated Lab-on-Chip devices for genomics and proteomics have been widely researched and developed over the past decade and have gained significant acceptance among biological and biomedical researchers. The next grand challenge is the miniaturization of laboratory automation technologies for handling and manipulating living biological cells, embryos and small organisms that would enable faster analysis, lower cost, greater precision and parallelization (high throughput) over existing methods. These devices are essential in many biological studies and procedures such as embryology, in-vitro fertilization, transgenics, stem cell engineering/ transformation and in toxicology. They are also critically important in the drug discovery process where increasingly, small model organisms such as Zebrafish and C.elegans are being used for determining potent drug candidates from millions of molecules in the chemical compound libraries.

用于基因组学和蛋白质组学的微加工芯片实验室设备在过去十年中得到了广泛的研究和开发，并在生物和生物医学研究人员中获得了显著的认可。下一个巨大的挑战是实验室自动化技术的小型化，用于处理和操纵活的生物细胞，胚胎和小生物体，这将使分析速度更快，成本更低，精度更高，并行化（高通量）超过现有的方法。这些设备在许多生物学研究和程序中是必不可少的，例如胚胎学、体外受精、转基因、干细胞工程/转化和毒理学。它们在药物发现过程中也至关重要，越来越多的小型模式生物如斑马鱼和秀丽隐杆线虫被用于从化合物库中的数百万分子中确定有效的候选药物。