Elucidation of structure-function relationships in biological systems utilising advanced electron spin resonance

利用先进的电子自旋共振阐明生物系统中的结构-功能关系

• 批准号: FT120100421
• 负责人: A/Prof Jeffrey Harmer
• 金额: $ 60.56万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT120100421
• 关键词: Elucidation; structure; function; relationships; biological

The human growth hormone receptor and mammalian P450 enzymes are implicated in numerous human disorders and the key to treatment is the rational design and delivery of drugs. This project will require a comprehensive understanding of the biological structure-function relationship which we will acquire using high-resolution electron spin resonance spectroscopy.

人类生长激素受体和哺乳动物的P450酶与许多人类疾病有关，治疗的关键是合理的药物设计和给药。这个项目将需要全面了解生物结构-功能关系，这是我们将使用高分辨率电子自旋共振光谱获得的。