Analysis of evolution of gene function through RNAi screens in nematodes

通过 RNAi 筛选线虫基因功能进化分析

• 批准号: 375470-2009
• 负责人: Fraser, Andrew
• 金额: $ 3.39万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=550194
• 关键词: Analysis; evolution; gene; function; through

All of biology is regulated by genes - they are the code that determines what each organism looks like and how it functions. To evolve a new structure like a brain or a thumb needs the evolution of new gene functions - how does this happen? Does evolution use the same old genes in new ways, much as one might build many different structures using the same building blocks? Or do new structures tend to need new building blocks, just as building a toy car needs us to have parts for wheels? These are key questions at the heart of our understanding of biology and evolution.

所有的生物都是由基因调控的--它们是决定每个生物体的样子和功能的密码。 为了进化出一个新的结构，比如大脑或拇指，需要进化出新的基因功能--这是如何发生的呢？ 进化是否以新的方式使用相同的旧基因，就像人们可能使用相同的积木建造许多不同的结构一样？或者，新的结构往往需要新的积木，就像建造玩具汽车需要我们有轮子的零件一样？这些是我们理解生物学和进化的核心问题。