Eliminating hazardous chemicals in key processes in the pharmaceutical sector

消除制药行业关键流程中的危险化学品

• 批准号: 430211-2012
• 负责人: Crudden, Cathleen
• 金额: $ 6.56万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=552537
• 关键词: Eliminating; hazardous; chemicals; key; processes

There are two key types of reactions that are involved in almost every chemical synthesis: carbon-carbon bond forming reactions, and functional group transformations. The former is essential for building up the carbon skeleton of a pharmaceutical, agrochemical, bulk or petrochemical. The latter is essential for decorating this skeleton with the chemical functionality that makes the chemical "work", for example, the functionality that allows a drug to interact with cells, or allows an agrochemical to work as a fertilizer. In addition, functional group manipulations are often needed to 'set-up' carbon carbon bond forming reactions such as oxidizing an alcohol to a ketone before a Grignard reaction. Oxidations and reductions are the two most common functional group interconversions. This proposal focuses on the latter transformation.

几乎每一种化学合成都涉及两种关键类型的反应：碳-碳键形成反应和官能团转化。前者对于构建制药、农用化学品、散装或石化产品的碳骨架至关重要。后者对于用化学功能装饰这个骨架是必不可少的，这种化学功能使化学物质发挥作用，例如，允许药物与细胞相互作用的功能，或允许农用化学品用作肥料的功能。此外，通常需要官能团操作来‘建立’碳碳键的形成反应，例如在格氏反应之前将醇氧化为酮。氧化和还原是两种最常见的官能团相互转化反应。这项建议侧重于后一种转型。