Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)

波多黎各探索污染威胁的试验场（PROTECT）

• 批准号: 10796254
• 负责人: Akram N Alshawabkeh
• 金额: $ 1.49万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10796254
• 关键词: Address; Back; Chemicals; Communities; Development; Education; Environmental Health; Exposure to; Family; Fetal Growth Retardation; Funding; General Population; Gestational Diabetes; Hazardous Chemicals; Health; Human; Incidence; Industry; Laboratories; Link; Low Birth Weight Infant; Medical; Mentors; Participant; Pesticides; Pharmacology and Toxicology; Poly-fluoroalkyl substances; Pre-Eclampsia; Pregnancy Outcome; Pregnant Women; Puerto Rico; Reporting; Research; Research Personnel; Risk; Science; Triclosan; Universities; Woman; Work; adverse pregnancy outcome; cohort; doctoral student; follow-up; interest; manufacture; medical schools; member; obesity in children; phthalates; professor; programs; skill acquisition; skills; social health determinants; study population; superfund site; triclocarban

PFAS and the impact on human health: From the laboratory to the community Since 2010, PROTECT (Puerto Rico Testsite for Exploring Contamination Threats) investigators have studied the effects of hazardous chemicals, commonly found at Superfund sites, on adverse pregnancy outcomes in women living in the Northern Karst region of Puerto Rico. The primary chemicals found to be present in the PROTECT cohort of pregnant women are pesticides, phthalates, bisphenols, triclosan, and triclocarban (Lewis et al, 2014; Ferguson et al., 2019; Aker et al., 2019). PFAS (per- and poly-fluoroalkyl substances) are a class of over 12,000 chemicals that have been manufactured and used in a variety of industries worldwide since the 1940s. There is evidence that exposure to PFAS is linked with detrimental effects on human health. In pregnant women, PFAS exposure has been associated with low birth weight (Ashley et al., 2017) and increased incidence of gestational diabetes, childhood obesity, preeclampsia, and fetal growth restriction (Szilagyi et al., 2020). Despite the increased number of contaminants studied in PROTECT, the presence of PFAS in pregnant women, their families, and the general population in Puerto Rico is unknown. This request for KC Donnelly funding starts to address this need for more exploratory research. I am a doctoral student in Social Determinants of Health at the University of Puerto Rico Medical Sciences Campus. As a member of the PROTECT team since 2019, I am particularly interested in the effects of hazardous chemicals on pregnancy outcomes. I am also very active in the Community and Engagement Core and the initiative to provide results of harmful exposures and follow-up education for risk avoidance to our study participants through the Report Back program. My project has two Specific Aims, one that will broaden my environmental health science skills under the guidance of Dr. Jamie DeWitt, a professor in the Department of Pharmacology and Toxicology at the Brody School of Medicine at East Carolina University. The second aim is to work with my mentors in PROTECT (Drs. Velez-Vega and Brown) to apply my newly acquired skills toward the development of an educational program that will enhance our Report Back initiative to the benefit our study population as well as all communities in Puerto Rico that need to be informed about the risks of PFAS exposure.

PFAS及其对人类健康的影响：从实验室到社区 自2010年以来，APTT（波多黎各探索污染威胁试验场） 调查人员研究了危险化学品的影响，这些化学品通常在超级基金中发现， 网站，对生活在波多黎各北方喀斯特地区的妇女的不良妊娠结局 瑞可发现存在于孕妇中的主要化学物质 是杀虫剂、邻苯二甲酸盐、双酚、三氯生和三氯卡班（刘易斯等人，2014;弗格森等人，2015）。 例如，2019; Aker等人，2019年）。 PFAS（全氟烷基和多氟烷基物质）是一类超过12，000种化学品， 自20世纪40年代以来，已在世界各地的各种行业中制造和使用。有 有证据表明，接触PFAS与对人类健康的有害影响有关。妊娠 对于女性，PFAS暴露与低出生体重有关（阿什利等人，2017）和 妊娠期糖尿病、儿童肥胖、先兆子痫和胎儿生长的发病率增加 限制（Szilagyi等人，2020年）。尽管研究的污染物数量增加， 孕妇、其家人和一般人群中存在PFAS 在波多黎各是未知的。KC Donnelly资金的这一请求开始解决这一需求， 更多探索性研究 我是波多黎各大学健康社会决定因素专业的博士生 医学科学校园。自2019年以来，我一直是TMT团队的一员， 对危险化学品对怀孕结果的影响感兴趣。我也非常积极地参与 社区和参与核心以及提供有害暴露结果的倡议 并透过报告向参与者提供有关风险防范的跟进教育。 程序.我的项目有两个具体目标，一个是扩大我的环境健康 科学技能的指导下博士杰米德威特，在系教授 东卡罗莱纳大学布罗迪医学院药理学和毒理学。的 第二个目标是与我的导师（Velez-Vega博士和Brown博士）合作， 新获得的技能，以发展一个教育计划，将提高我们的 报告返回倡议，以造福我们的研究人口以及在波多黎各的所有社区 Rico需要了解PFAS暴露的风险。

项目成果

PVC biodeterioration and DEHP leaching by DEHP-degrading bacteria.

• DOI: 10.1016/j.ibiod.2011.12.011
• 发表时间: 2012-04-01
• 期刊: INTERNATIONAL BIODETERIORATION & BIODEGRADATION
• 影响因子: 4.8
• 作者: Latorre, Isomar;Hwang, Sangchul;Sevillano, Maria;Montalvo-Rodriguez, Rafael
• 通讯作者: Montalvo-Rodriguez, Rafael

Optimization of electrochemical dechlorination of trichloroethylene in reducing electrolytes.

• DOI: 10.1016/j.watres.2012.01.002
• 发表时间: 2012-04-15
• 期刊: WATER RESEARCH
• 影响因子: 12.8
• 作者: Mao, Xuhui;Ciblak, Ali;Baek, Kitae;Amiri, Mohammad;Loch-Caruso, Rita;Alshawabkeh, Akram N.
• 通讯作者: Alshawabkeh, Akram N.

Effects of reduced sulfur compounds on Pd-catalytic hydrodechlorination of trichloroethylene in groundwater by cathodic H2 under electrochemically induced oxidizing conditions.

• DOI: 10.1021/es402169d
• 发表时间: 2013-09-17
• 期刊: ENVIRONMENTAL SCIENCE & TECHNOLOGY
• 影响因子: 11.4
• 作者: Yuan, Songhu;Chen, Mingjie;Mao, Xuhui;Alshawabkeh, Akram N.
• 通讯作者: Alshawabkeh, Akram N.

The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide.

• DOI: 10.1016/j.mrgentox.2019.02.001
• 发表时间: 2019-04
• 期刊: Mutation research. Genetic toxicology and environmental mutagenesis
• 作者: Mark Muenter;Ariel A. Aiken;Jadesola O. Akanji;Samir Baig;S. Bellou;Alyssa L Carlson;Charles Conway;Courtney M Cowell;Nicholas A. DeLateur;Alexis Hester;Christopher Joshi;Caitlin Kramer;Becky S. Leifer;Emma Nash;Ma Qi;M. Travers;Kelly Wong;Man Hu;Na Gou;R. Giese;A. Gu;P. Beuning

Machine learning-based biomarkers identification from toxicogenomics - Bridging to regulatory relevant phenotypic endpoints.

• DOI: 10.1016/j.jhazmat.2021.127141
• 发表时间: 2022-02-05
• 期刊: JOURNAL OF HAZARDOUS MATERIALS
• 影响因子: 13.6
• 作者: Rahman, Sheikh Mokhlesur;Lan, Jiaqi;Kaeli, David;Dy, Jennifer;Alshawabkeh, Akram;Gu, April Z.
• 通讯作者: Gu, April Z.