Determining the role of E2A-PBX1, CBP/p300 and EBF1 in the onset of acute lymphoblastic leukemia.
Determining the role of E2A-PBX1, CBP/p300 and EBF1 in the onset of acute lymphoblastic leukemia.
批准号:
300773
负责人:
Langelaan David N
金额:
$9.83万
依托单位国家:
加拿大
项目类别:
Fellowship Programs
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-11-01 至 2016-11-01
中文摘要
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英文摘要
The transcription factor E2A is essential for the regulation of B-cell development. In approximately 25% of pre-B acute lymphoblastic leukemia (ALL) cases, a genetic mutation results in expression of the oncogene E2A-PBX1. E2A-PBX1 is thought to contribut
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