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Development of high-yielding stereoselective methodologies for the synthesis of Active Pharmaceutical Ingredients (API)

Development of high-yielding stereoselective methodologies for the synthesis of Active Pharmaceutical Ingredients (API)
开发用于合成活性药物成分 (API) 的高产立体选择性方法
批准号：
462733-2014
负责人：
Dudding, Travis
金额：
$1.79万
依托单位：
Brock University
依托单位国家：
加拿大
项目类别：
Engage Grants Program
财政年份：
2014
资助国家：
加拿大
项目状态：
已结题
起止时间：
2014-01-01 至 2015-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=558007
关键词：
Developmentyieldingstereoselectivemethodologiessynthesis

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英文摘要
The proposed collaborative project with Alphora Research involves the development of synthetic processes for manufacturing precursors for a group of chemical compounds called halichondrin polycyclic macrolides, which have potential as cancer drugs. These anti-tumour substances are related to halichondrin B, a natural product that was isolated from a marine sponge. Health Canada and the FDA have recently approved the fully synthetic analog eribulin for treatment of certain metastatic breast cancers; however, the manufacturing process is not yet efficient for this and related substances. We will focus our efforts in improving the methodologies for some of the steps in the preparation of this medicinally important group of compounds.
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