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Developing an optogenetically-inspired deep brain stimulation protocol to normalize synaptic transmission and abolish pathological behaviour in a SAPAP3 knock-out model of obsessive-compulsive disorder

Developing an optogenetically-inspired deep brain stimulation protocol to normalize synaptic transmission and abolish pathological behaviour in a SAPAP3 knock-out model of obsessive-compulsive disorder
开发一种受光遗传学启发的深部脑刺激方案，以使突触传递正常化并消除强迫症 SAPAP3 敲除模型中的病理行为
批准号：
318680
负责人：
Creed Meaghan
金额：
$9.41万
依托单位：
Centre mdical universitaire de Genève (Geneve, Switzerland)
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2014
资助国家：
加拿大
项目状态：
已结题
起止时间：
2014-11-01 至 2017-06-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=318680&lang=en
关键词：
Channelrhodopsin Deep Brain Stimulation Dopamine Glutamate In Vivo Electrophysiology Obsessive Compulsive Disorder Optogenetics Patch Clamp Electrophysiology Sapap3 Synaptic Plasticity

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英文摘要
Circuit dysfunction resulting from pathological forms of synaptic plasticity underlies several psychiatric diseases, including obsessive compulsive disorder (OCD). OCD is a debilitating disorder characterized by intrusive thoughts (obsessions) and repetit
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