Structure, organization and reactivity in organic monolayers: impacts on material functionality

有机单分子层的结构、组织和反应性:对材料功能的影响

基本信息

  • 批准号:
    RGPIN-2014-03977
  • 负责人:
  • 金额:
    $ 2.48万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2014
  • 资助国家:
    加拿大
  • 起止时间:
    2014-01-01 至 2015-12-31
  • 项目状态:
    已结题

项目摘要

This multidisciplinary program focuses on the structure, organization and properties of one molecule thick films either at the interface between air and water or coating a solid surface. The main objectives of this research are to investigate these phenomena using lipids, lipid analogues and surfactants and to use this knowledge to understand biological membrane organization, to develop new materials/surface coatings and to evaluate the effect of environmental pollution on biological systems The physical properties of lipid membranes and surfactant films are critical for understanding biological processes and industrial applications (e.g. emulsion technology, pharmaceuticals, drug delivery, food industry, personal care products etc.). Langmuir monolayers at the air-water interface are commonly used as models of biological membranes, as a means to pre-organize materials for thin films and to understand self-assembly processes at interfaces. The properties of such monomolecular films are governed by a balance of different intermolecular interactions which we will probe using systematic variation of the surfactant/lipid chemical structure and external parameters (temperature, pH, salt). We then use this knowledge of monolayer properties for the design of functional materials, i.e. creating robust thin films coatings which then confer specific functionalities to the surface, e.g. biocompatibility, protein or cell binding capacity. This enables their use in bioapplications such as protein separations, biosensing and detection. Finally, understanding the influence of non-covalent interactions on lipid films enables us to evaluate biological membrane structure and property changes induced by atmospheric pollutants. We study the chemical damage to the lipid-protein film, which coats the lung surface and enables breathing, upon exposure to pollutants common in smog. This chemical damage may be responsible for the immediate impairment of respiratory function on days when air quality is low. This research may lead to new therapies or methods of detecting damaging levels of pollution.
这个多学科计划的重点是在空气和水之间的界面或涂层固体表面的一个分子厚膜的结构,组织和性能。本研究的主要目的是利用脂质、脂质类似物和表面活性剂来研究这些现象,并利用这些知识来了解生物膜组织,开发新材料/表面涂层,评估环境污染对生物系统的影响。脂膜和表面活性剂膜的物理性质对于理解生物过程和工业应用至关重要(例如乳液技术、制药、药物输送、食品工业、个人护理产品等)。在空气-水界面的朗缪尔单分子层通常被用作生物膜的模型,作为一种手段,以预组织薄膜材料和了解界面处的自组装过程。这样的单分子膜的性质是由不同的分子间相互作用的平衡,我们将探测使用系统的表面活性剂/脂质的化学结构和外部参数(温度,pH值,盐)的变化。然后,我们将单层特性的知识用于功能材料的设计,即创建坚固的薄膜涂层,然后赋予表面特定的功能,例如生物相容性,蛋白质或细胞结合能力。这使得它们能够用于生物应用,如蛋白质分离,生物传感和检测。最后,了解非共价相互作用对脂质膜的影响,使我们能够评估大气污染物引起的生物膜结构和性质的变化。我们研究了暴露于烟雾中常见的污染物后,对脂质蛋白膜的化学损伤,脂质蛋白膜覆盖在肺表面并使呼吸成为可能。在空气质量低的日子里,这种化学损伤可能是呼吸功能立即受损的原因。这项研究可能会导致新的治疗方法或检测污染损害程度的方法。

项目成果

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DeWolf, Christine其他文献

Formation of a Supported Lipid Bilayer on Faceted LiYF4: Tm3+/Yb3+ Upconversion Nanoparticles
  • DOI:
    10.1002/ppsc.201600218
  • 发表时间:
    2016-12-01
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Rojas-Gutierrez, Paola A.;DeWolf, Christine;Capobianco, John A.
  • 通讯作者:
    Capobianco, John A.
Structural organization and phase behaviour of meta-substituted dioctadecylaminobenzoquinones at the air/water interface
  • DOI:
    10.1039/c8cp07186a
  • 发表时间:
    2019-02-07
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Behyan, Shirin;Gritzalis, Dimitrios;DeWolf, Christine
  • 通讯作者:
    DeWolf, Christine
Membrane selectivity and biophysical studies of the antimicrobial peptide GL13K
  • DOI:
    10.1016/j.bbamem.2013.05.027
  • 发表时间:
    2013-09-01
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Balhara, Vinod;Schmidt, Rolf;DeWolf, Christine
  • 通讯作者:
    DeWolf, Christine
Nanoparticle-induced structural changes in lung surfactant membranes: an X-ray scattering study
  • DOI:
    10.1039/c8en00189h
  • 发表时间:
    2018-05-01
  • 期刊:
  • 影响因子:
    7.3
  • 作者:
    Behyan, Shirin;Borozenko, Olga;DeWolf, Christine
  • 通讯作者:
    DeWolf, Christine
A biophysical study of tear film lipid layer model membranes

DeWolf, Christine的其他文献

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{{ truncateString('DeWolf, Christine', 18)}}的其他基金

Optical tensiometer for biological and materials science research
用于生物和材料科学研究的光学张力计
  • 批准号:
    RTI-2023-00528
  • 财政年份:
    2022
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Research Tools and Instruments
How Interfacial Structure and Organization Govern Biological and Material Functionality
界面结构和组织如何控制生物和材料功能
  • 批准号:
    RGPIN-2019-07043
  • 财政年份:
    2022
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
How Interfacial Structure and Organization Govern Biological and Material Functionality
界面结构和组织如何控制生物和材料功能
  • 批准号:
    RGPIN-2019-07043
  • 财政年份:
    2021
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
How Interfacial Structure and Organization Govern Biological and Material Functionality
界面结构和组织如何控制生物和材料功能
  • 批准号:
    RGPIN-2019-07043
  • 财政年份:
    2020
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Structure, organization and reactivity in organic monolayers: impacts on material functionality
有机单分子层的结构、组织和反应性:对材料功能的影响
  • 批准号:
    RGPIN-2014-03977
  • 财政年份:
    2018
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Structure, organization and reactivity in organic monolayers: impacts on material functionality
有机单分子层的结构、组织和反应性:对材料功能的影响
  • 批准号:
    RGPIN-2014-03977
  • 财政年份:
    2017
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Structure, organization and reactivity in organic monolayers: impacts on material functionality
有机单分子层的结构、组织和反应性:对材料功能的影响
  • 批准号:
    RGPIN-2014-03977
  • 财政年份:
    2016
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Structure, organization and reactivity in organic monolayers: impacts on material functionality
有机单分子层的结构、组织和反应性:对材料功能的影响
  • 批准号:
    RGPIN-2014-03977
  • 财政年份:
    2015
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Structure at interfaces: applications in biology, nanotechnology & the atmosphere
界面结构:生物学、纳米技术中的应用
  • 批准号:
    249948-2007
  • 财政年份:
    2013
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Structure at interfaces: applications in biology, nanotechnology & the atmosphere
界面结构:生物学、纳米技术中的应用
  • 批准号:
    249948-2007
  • 财政年份:
    2012
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual

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