Interactive Modeling of Multi-scale Biological Systems

多尺度生物系统的交互建模

• 批准号: RGPIN-2014-06094
• 负责人: Jacob, Christian
• 金额: $ 2.33万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=567591
• 关键词: Interactive; Modeling; Multi; scale; Biological

I am interested in understanding in emergent properties of seemingly complex systems, where “the sum is greater than its parts”. For more than a decade, I have been collaborating with biologists, medical researchers, and medical educators to design and test computational models of biological systems. Biologists tend to think about their objects of study as discrete entities. Computationally, these entities can be represented by ‘agents’, whose interaction rules are known or can be identified, and ultimately represented by ‘simple programs’ with concise algorithmic descriptions. Once such interacting elements are arranged within compartments, which are organized into interconnected larger units (‘universes’), complex behaviors emerge. As a computer scientist I look at how to capture, illustrate and make seemingly complex systems explorable through 3-dimensional, interactive computer models. The agent-based models, that we develop in my Evolutionary & Swarm Design research lab, help to communicate our fundamental understanding of complex systems. Going beyond carefully crafted animations, the development of new algorithms and methodologies to build such models does not only enhance research in “systems” sciences but creates new computational approaches for generating, visualizing, and exploring complex models in simulated 3D spaces. “To see is to begin to understand”. And to explore our own learning paths through interactive models deepens our understanding. The next steps in my research focus on how to integrate multi-scale models across different levels of resolution in space and time. My current research focus is on how to combine continuous mathematical models with agent-based approaches. The mathematical models capture concentration changes averaged over a large number of particles (such as molecules), whereas agent methods are a better fit for representing entities that appear in small quantities, and where specific interactions among these entities (such as proteins or cells) can be modeled to a high level of detail in 3D. As many complex systems are composed of a hierarchy of subsystems across a range of scales (e.g., from systems and organs to tissues, cells, and proteins), multi-scale computational models need to incorporate and integrate processes that occur at different spatial scales and at different resolutions in time. Making multi-scale models accessible is another important aspect in my research. I investigate user interfaces for visualization, navigation, presentation, and exploration of model hierarchies across temporal and spatial scales. At the same time, I want our models to be run in real time while maintaining interactivity at any point. I strive to make complex models accessible to a wider user base, by exploring solutions for running simulations on mobile computing platforms.

我感兴趣的是理解看似复杂的系统的涌现特性，其中“总和大于其部分”。十多年来，我一直与生物学家，医学研究人员和医学教育工作者合作，设计和测试生物系统的计算模型。生物学家倾向于把他们的研究对象看作是离散的实体。在计算上，这些实体可以由“代理”表示，其交互规则是已知的或可以识别的，并最终由具有简洁算法描述的“简单程序”表示。一旦这些相互作用的元素被安排在隔间中，这些隔间被组织成相互连接的更大单元（“宇宙”），复杂的行为就会出现。作为一名计算机科学家，我研究如何通过三维交互式计算机模型捕获、说明和探索看似复杂的系统。我们在进化与群体设计研究实验室开发的基于代理的模型有助于传达我们对复杂系统的基本理解。超越精心制作的动画，开发新的算法和方法来构建这样的模型不仅可以增强“系统”科学的研究，而且可以创建新的计算方法来生成，可视化和探索模拟3D空间中的复杂模型。“看见就是开始理解”。通过交互式模型探索我们自己的学习路径加深了我们的理解。我研究的下一步重点是如何在空间和时间的不同分辨率水平上集成多尺度模型。我目前的研究重点是如何将联合收割机连续数学模型与基于主体的方法相结合。数学模型捕获大量粒子（如分子）的平均浓度变化，而代理方法更适合表示少量出现的实体，并且可以在3D中对这些实体（如蛋白质或细胞）之间的特定相互作用进行建模。由于许多复杂系统是由跨越一系列尺度的子系统的层次结构组成的（例如，从系统和器官到组织、细胞和蛋白质），多尺度计算模型需要合并和整合在不同空间尺度和不同时间分辨率下发生的过程。使多尺度模型可访问是我研究的另一个重要方面。我调查用户界面的可视化，导航，演示和探索跨时空尺度的模型层次结构。同时，我希望我们的模型能够在真实的时间内运行，同时在任何时候都保持交互性。通过探索在移动的计算平台上运行模拟的解决方案，我努力使更广泛的用户群可以访问复杂的模型。