"Computer-aided Diagnosis in Ophthalmology, Dermatology, and Radiology"

计算机辅助诊断（CAD）的几种类型的疾病是可能的数字图像处理和模式识别的专业技术的应用，这是我的研究计划的主题。我建议开发CAD技术在眼科，皮肤科和放射科的几个应用。 糖尿病、高血压和早产儿视网膜病（ROP）等几种疾病会影响视网膜中的血管;具体而言，血管的形状和宽度会因病理过程而改变。视网膜血管结构的定量分析可以帮助监测疾病的阶段，评估对视觉系统的影响，并评估对治疗的反应。我建议开发图像处理技术来检测和分析视网膜眼底图像中的血管，检测和建模主要的颞弓，并制定措施，以促进ROP的客观分级和随访。我建议开发算法来分析的形状，宽度和曲折的血管使用形状因子，连贯性，角度偏差和分形分析。我将开发参数方法，以促进纵向定量分析，以帮助随访ROP患者和评估治疗效果。这些方法将在阿尔伯塔儿童医院用病人的图像进行测试。 我打算继续与巴西、英国、西班牙、印度、中国和意大利的研究人员建立富有成效的合作关系。这些项目包括肌肉骨骼畸形（椎骨骨折和脊柱变形）、皮肤溃疡（组织成分分割和分析）和乳腺癌（肿瘤、双侧不对称和结构变形分析）的计算机辅助设计。提出的图像处理和模式识别技术将有助于对医学图像进行客观和定量的分析。我的研究计划将导致有效和准确的CAD和改善患者的预后。

Computer-aided diagnosis (CAD) of several types of diseases is possible by the application of specialized techniques of digital image processing and pattern recognition; this is the theme of my research program. I propose to develop CAD techniques for several applications in ophthalmology, dermatology, and radiology. Several conditions such as diabetes, hypertension, and retinopathy of prematurity (ROP) affect the blood vessels in the retina; specifically, the shape and width of the vessels are modified by pathological processes. Quantitative analysis of the architecture of the retinal vasculature could assist in monitoring the stage of a disease, evaluating the effects on the visual system, and assessing the response to treatment. I propose to develop image processing techniques to detect and analyze blood vessels in fundus images of the retina, to detect and model the major temporal arcade, and to develop measures to facilitate objective grading and followup of ROP. I propose to develop algorithms to analyze the shape, width, and tortuosity of blood vessels using shape factors, coherence, angular deviation, and fractal analysis. I will develop parametric methods to facilitate longitudinal quantitative analysis to aid followup of patients with ROP and assessment of the effect of treatment. The methods will be tested with images of patients at the Alberta Children's Hospital. I propose to continue the productive collaboration I have established with researchers in Brazil, UK, Spain, India, China, and Italy. The projects include CAD of musculoskeletal deformities (fracture of the vertebrae and distortion of the spine), dermatological ulcers (segmentation and analysis of tissue composition), and breast cancer (analysis of tumors, bilateral asymmetry, and architectural distortion). The proposed techniques of image processing and pattern recognition will facilitate objective and quantitative analysis of medical images. My research program will lead to efficient and accurate CAD and improved prognosis for patients.