Modification and characterisation of surfaces and plasma processes for biotechnological applications

用于生物技术应用的表面和等离子体工艺的改性和表征

• 批准号: 156016-2011
• 负责人: Laroche, Gaétan
• 金额: $ 2.19万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=569502
• 关键词: Modification; characterisation; surfaces; plasma; processes

Surface modification technologies allow improving the biocompatibility of materials to be implanted in the human body. One of these surface modification technologies involves immersing materials within plasmas which basically consist in gaseous species that are excited using an external energy field. This leads to the activation of the surface which then becomes suited for the attachment of biocompatible molecules. On one hand, this research will focus on the characterisation of the plasmas that are used to modify the surface of biomaterials. The objective of this part of the project will be to determine the chemistry of the plasma treated surfaces from the physicochemical properties of the plasmas. One the other hand, this project will be devoted to understand the conditions that allow preserving biomolecules bioactivity upon surface grafting with a particular interest on the effect of surface hydrophilicity, distance between the surface and the biomolecule, and biomolecule conjugation site. The outcomes of this research program (in situ monitoring of plasmas to predetermine their surface chemistry and knowledge of the parameters to maintain biomolecule bioactivity upon surface conjugation) will be highly relevant for future developments in the field of implantable biomaterials.

表面改性技术可以提高植入人体的材料的生物相容性。其中一种表面改性技术涉及将材料浸入等离子体中，等离子体主要存在于利用外部能量场激发的气体物种中。这导致了表面的活化，然后表面变得适合于生物相容分子的附着。 一方面，这项研究将集中在用于修饰生物材料表面的等离子体的表征上。该项目这一部分的目标将是根据等离子体的物理化学性质确定经等离子体处理的表面的化学成分。另一方面，本项目将致力于了解允许生物分子在表面嫁接时保持生物活性的条件，特别是表面亲水性、表面与生物分子之间的距离以及生物分子结合部位的影响。 这项研究计划的结果(对血浆进行原位监测以预先确定其表面化学成分，以及了解在表面连接时保持生物分子生物活性的参数)将与植入性生物材料领域的未来发展高度相关。