3D printing of topographic features on dental implant surfaces to promote osseointegration

任何植入物的长期成功都密切依赖于各种参数的相互关系，包括散装材料的生物相容性、植入物表面的宏观和微观特征、植入床的状态（宿主骨质量和数量）以及手术技术本身。在牙科植入物的情况下，生物相互作用主要发生在骨组织和材料之间的界面处。因此，种植体的表面性能在预测其临床成功率方面起着至关重要的作用，在这种背景下，表面改性方法最近在生物材料研究中获得了重要和决定性的地位，作为控制种植体骨结合速度和质量的工具。目前的项目旨在在口腔种植学中使用的传统材料表面创建明确的地形，因为越来越多的证据表明骨细胞能够感知并响应地形线索，因此，我们的目标是确定有助于早期骨整合和确保长期骨-种植体锚定的地形特征。

The long-term success of any implant is closely dependent on the interrelationship of various parameters,including biocompatibility of the bulk material, macroscopic and microscopic features of the implant surface,the status of the implant bed (host bone quality and quantity) and the surgical technique per se. In the case ofdental implants, the biological interactions take largely place at the interface between the bone tissue and thematerial. Consequently, the surface properties of implants play a crucial role in predicting their clinical success.In this context, the surface modification approach has recently gained an important and decisive place inbiomaterials research, as tool to control the rate and quality of implant osseointegration. The current projectseeks to create well-defined topographies on the surface of conventional materials used in oral implantologybecause there is growing evidence suggesting that bone cells perceive and respond to topographical cues.Therefore, our objective is to determine topographical features that facilitate early osseointegration and ensurelong-term bone-implant anchorage.