New Developments in Organic Chemistry: Methods and Total Synthesis

有机化学新进展：方法与全合成

• 批准号: 170204-2013
• 负责人: Batey, Robert
• 金额: $ 5.03万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=569557
• 关键词: New; Developments; Organic; Chemistry; Methods

The proposed research program is aimed at the development of novel strategies and new synthetic methods and reagents for the efficient formation of carbon-carbon and carbon-heteroatom bonds. Methods that can generate products in a selective manner, whether in a site selective, chemoselective or stereoselective fashion are of particular importance, since they can then be used for the controlled and predictable synthesis of complex molecules. The use of transition metal catalysis provides one approach to achieve this goal, while the development of domino reaction sequences will allow for the rapid construction of molecular complexity. Specific projects outlined in the current proposal include the development of pericyclic reactions, organoboron and alkyne chemistry. The scope of these methods and, where appropriate, the mechanism of the reactions will be determined. The synthetic methods will be applied directly to the syntheses of biologically relevant and structurally complex taregt molecules, including natural products which display anticancer or antibiotic activity, such as macrocylic depsipeptides and alkaloids. General methods, reactions and reagents that are of broad applicability ultimately result in practical benefits to other synthetic organic chemists, both in academic labs and commercial labs. Overall the proposed program will not only advance basic research in science and technology, but will also provide a training and research environment for students interested in research and development careers in the pharmaceutical, biotechnology, medicinal, agrochemical, and high-tech materials sectors.

拟议的研究计划旨在开发新的策略和新的合成方法和试剂，以有效形成碳-碳和碳-杂原子键。能够以选择性方式（无论是以位点选择性、化学选择性还是立体选择性方式）产生产物的方法是特别重要的，因为它们随后可用于复杂分子的受控和可预测的合成。过渡金属催化的使用提供了实现这一目标的一种方法，而多米诺反应序列的发展将允许快速构建分子复杂性。目前提案中概述的具体项目包括周环反应、有机硼和炔化学的发展。将确定这些方法的范围，并在适当情况下确定反应机理。该合成方法将直接应用于生物学相关和结构复杂的taregt分子的合成，包括显示抗癌或抗生素活性的天然产物，如大环缩酚肽和生物碱。 具有广泛适用性的一般方法，反应和试剂最终会为学术实验室和商业实验室的其他合成有机化学家带来实际利益。总体而言，拟议的计划不仅将推进科学和技术的基础研究，而且还将为对制药，生物技术，医药，农业化学和高科技材料领域的研究和开发事业感兴趣的学生提供培训和研究环境。