New Developments in Organic Chemistry: Methods and Total Synthesis

有机化学新进展：方法与全合成

• 批准号: 170204-2013
• 负责人: Batey, Robert
• 金额: $ 5.03万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632796
• 关键词: New; Developments; Organic; Chemistry; Methods

The proposed research program is aimed at the development of novel strategies and new synthetic methods and reagents for the efficient formation of carbon-carbon and carbon-heteroatom bonds. Methods that can generate products in a selective manner, whether in a site selective, chemoselective or stereoselective fashion are of particular importance, since they can then be used for the controlled and predictable synthesis of complex molecules. The use of transition metal catalysis provides one approach to achieve this goal, while the development of domino reaction sequences will allow for the rapid construction of molecular complexity. Specific projects outlined in the current proposal include the development of pericyclic reactions, organoboron and alkyne chemistry. The scope of these methods and, where appropriate, the mechanism of the reactions will be determined. The synthetic methods will be applied directly to the syntheses of biologically relevant and structurally complex taregt molecules, including natural products which display anticancer or antibiotic activity, such as macrocylic depsipeptides and alkaloids. General methods, reactions and reagents that are of broad applicability ultimately result in practical benefits to other synthetic organic chemists, both in academic labs and commercial labs. Overall the proposed program will not only advance basic research in science and technology, but will also provide a training and research environment for students interested in research and development careers in the pharmaceutical, biotechnology, medicinal, agrochemical, and high-tech materials sectors.

拟议的研究计划旨在开发新的战略和新的合成方法和试剂，以有效地形成碳-碳和碳-杂原子键。能够以选择性的方式产生产物的方法特别重要，因为它们可以用于复杂分子的可控和可预测的合成。过渡金属催化的使用为实现这一目标提供了一种方法，而多米诺骨牌反应序列的发展将允许快速构建分子复杂性。本提案中概述的具体项目包括发展周环反应、有机硼和炔化学。将确定这些方法的范围，并酌情确定反应的机理。这些合成方法将直接应用于生物相关和结构复杂的taregt分子的合成，包括具有抗癌或抗生素活性的天然产物，如大环多肽和生物碱。具有广泛适用性的一般方法、反应和试剂最终会给其他合成有机化学家带来实际好处，无论是在学术实验室还是商业实验室。总体而言，拟议的计划不仅将促进科学技术的基础研究，还将为对制药、生物技术、医药、农用化学品和高科技材料领域的研究和开发职业感兴趣的学生提供一个培训和研究环境。