The molecular basis of thyroid and lung development

甲状腺和肺发育的分子基础

• 批准号: 183875-2011
• 负责人: Drysdale, Thomas
• 金额: $ 2.91万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=569666
• 关键词: molecular; basis; thyroid; lung; development

Endoderm is a term that describes the interior layer of an early embryo. This layer will generate a simple tube that will give rise to many important organs including the thyroid, lung, pancreas, liver, and stomach. These organs arise from specific points along the tube in a precise spatial order. The thyroid comes from the very front of the tube and the lung comes from endoderm located further back. At the earliest stages of development, these two regions share many genes that are essential for their eventual development and so we wish to discover what makes the two organs different. We have found that addition of retinoic acid, the active form of vitamin A, causes the thyroid to turn off several important thyroid genes and turn on genes that are normally only expressed in lung. Our goal is to understand this switch in developmental fate. We will also exploit this switch to search for new genes that important for making a thyroid or a lung. Once we have obtained genes that are expressed in one organ or the other, we will manipulate those genes to examine their effect on thyroid and lung differentiation. By doing so we hope to gain a better understanding of the molecular network needed for the normal development of these endodermal organs.

内胚层是描述早期胚胎内层的术语。此层将生成一个简单的管 这将产生许多重要的器官，包括甲状腺，肺，胰腺，肝脏和胃。这些 器官以精确的空间顺序从沿着管的特定点产生。甲状腺来自于 管和肺的前面来自位于更后面的内胚层。最初阶段 发育，这两个区域共享许多对其最终发育至关重要的基因，因此我们 希望能发现这两种器官的不同之处我们已经发现，添加视黄酸， 维生素A的一种形式，导致甲状腺关闭几个重要的甲状腺基因并打开一些重要的基因 通常只在肺中表达。我们的目标是了解这种发展命运的转变。我们还将 利用这一开关来寻找对制造甲状腺或肺很重要的新基因。一旦我们 获得在一个器官或另一个器官中表达的基因，我们将操纵这些基因来检查它们的功能。 对甲状腺和肺分化的影响。通过这样做，我们希望能够更好地了解分子 这些内胚层器官的正常发育所需的网络。