The Role of Glucocorticoid-induced Tumour Necrosis Factor Receptor (GITR) Co-Stimulation in Establishing Early Viral Control during Chronic Viral Infection

糖皮质激素诱导的肿瘤坏死因子受体 (GITR) 共刺激在慢性病毒感染期间建立早期病毒控制中的作用

• 批准号: 331231
• 负责人: Chang Yu-Han
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-12-01 至 2015-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=331231&lang=en
• 关键词: Antigen Presenting Cells (Apc) Subsets; Cd4 T Helper Cell; Cd8 Cytotoxic T Cell; Chronic Lymphocytic Choriomeningitis Virus (Lcmv); Chronic Viral Infection; Gitr-Dependent T Cell Co-Stimulation; Glucocorticoid-Induced Tnf Receptor (Gitr); Glucocorticoid-I

Despite advances in antiviral therapy, chronic viral infections remain a major burden on global health. Normally upon viral infection, our immune system up-regulates an array of molecules on white blood cells to stimulate immune responses required for vir

尽管抗病毒治疗取得了进展，但慢性病毒感染仍然是全球卫生的一个主要负担。通常在病毒感染时，我们的免疫系统会上调白细胞上的一系列分子，以刺激病毒所需的免疫反应