Investigating CD4+ T helper cell differentiation during blood-stage Plasmodium infection

研究血液阶段疟原虫感染期间 CD4 T 辅助细胞的分化

• 批准号: nhmrc : 1028634
• 负责人: A/Pr Ashraful Haque
• 金额: $ 27.23万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-cd4-t-plasmodium-infection/110655
• 关键词: Investigating; CD4+; helper; cell; differentiation

Some infections tend to afflict us only once, e.g. chickenpox, because our bodies develop immunity to these microbes relatively easily. In contrast, it takes many infections to develop immunity to the malaria parasite, because our immune systems seem to respond inefficiently to it. My work will improve our understanding of how the immune system is poorly activated during malaria, and may provide new ideas for boosting the immune system in response to malaria or indeed other infections.

有些感染往往只折磨我们一次，例如水痘，因为我们的身体相对容易对这些微生物产生免疫力。相比之下，需要多次感染才能产生对疟疾寄生虫的免疫力，因为我们的免疫系统似乎对它的反应效率低下。我的工作将提高我们对疟疾期间免疫系统如何被激活的理解，并可能为增强免疫系统对疟疾或其他感染的反应提供新的想法。