Regulation of virus-specific CD4 T helper cell responses in viral hepatitis (04)

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CD4 T helper cells are central players in the regulation of the antiviral immune response. They are particularly important for the maintenance of cytotoxic CD8 T cell responses and the emergence of antibody-producing B cells. Distinct subpopulations of the CD4 T helper compartment are involved in these functions. This project aims to define the composition of the CD4 T helper compartment in the setting of acute and chronic viral hepatitis. These observations could provide a blueprint of successful CD4 T cell responses that could inform vaccine design.