Regulation of virus-specific CD4 T helper cell responses in viral hepatitis (04)

病毒性肝炎中病毒特异性 CD4 T 辅助细胞反应的调节 (04)

• 批准号: 316253495
• 金额: --
• 依托单位: Klinik für Innere Medizin II - Gastroenterologie, Hepatologie, Endokrinologie und Infektiologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/316253495?language=en
• 关键词: Regulation; virus; specific; CD4; helper

CD4 T helper cells are central players in the regulation of the antiviral immune response. They are particularly important for the maintenance of cytotoxic CD8 T cell responses and the emergence of antibody-producing B cells. Distinct subpopulations of the CD4 T helper compartment are involved in these functions. This project aims to define the composition of the CD4 T helper compartment in the setting of acute and chronic viral hepatitis. These observations could provide a blueprint of successful CD4 T cell responses that could inform vaccine design.

CD4辅助性T细胞是调节抗病毒免疫应答的核心参与者。它们对于维持细胞毒性CD8 T细胞应答和产生抗体的B细胞的出现特别重要。不同的亚群的CD4辅助性T细胞室参与这些功能。该项目旨在确定急性和慢性病毒性肝炎中CD4辅助性T细胞区室的组成。这些观察结果可以提供成功的CD4 T细胞应答的蓝图，可以为疫苗设计提供信息。