Improved mechanical blood damage modeling for medical device optimization

改进机械血液损伤模型以优化医疗设备

• 批准号: 283321-2010
• 负责人: Farinas, MarieIsabelle
• 金额: $ 1.53万
• 依托单位: Université du Québec à Chicoutimi
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571338
• 关键词: Improved; mechanical; blood; damage; modeling

The main goal of this research proposal is the improvement or optimization of medical devices (hemodialysis cannulas, blood pumps) with a focus on the numerical blood trauma modeling and validation. This high level research activity has important application to the Canadian health care system as it will lead to advanced medical devices (improved treatment) hence improvements in the quality of life of the Canadian population. Besides cost issues are critical so that it is important to enhance design tools to improve the performance of these devices while simultaneously reducing their costs. The improvement of the numerical prediction capabilities of our blood damage model (hemolysis-destruction of red blood cells) will arise from a thorough investigation of the medical device's flow regime, as it implies time-dependent instabilities (chaotic behavior) which are difficult to characterize and may be well within the transitional laminar-turbulent regime. Furthermore a stochastic approach to account for uncertainty quantification of the blood behavior at the micro-scale level will be investigated in order to bridge this information with the continuum approach. Then we will improve medical devices design optimization loop by incorporating the improved blood damage model as a cost function and validating the modeling assumptions with experimental data. This information will contribute to the development of a patient-specific diagnostic numerical tool for the practitioners with thorough experimental and numerical flow investigations of patient-specific vessels (carotid artery and aneurism). Indeed such a tool would improve the prospects for prevention, earlier diagnostic and improved treatment and prognostic of serious health conditions such as vascular and cardiovascular diseases.

本研究提案的主要目标是改进或优化医疗器械（血液透析插管、血泵），重点是数值血液创伤建模和验证。这项高水平的研究活动对加拿大的医疗保健系统有重要的应用，因为它将导致先进的医疗设备（改善治疗），从而改善加拿大人口的生活质量。此外，成本问题是至关重要的，因此重要的是要增强设计工具，以提高这些设备的性能，同时降低其成本。 我们的血液损伤模型（红细胞的溶血-破坏）的数值预测能力的提高将来自对医疗器械流动状态的彻底调查，因为它意味着时间依赖性不稳定性（混乱行为），这些不稳定性很难描述并且可能很好地处于过渡层湍流状态。此外，一个随机的方法来解释在微观尺度上的血液行为的不确定性量化将进行调查，以桥梁这一信息与连续的方法。然后，我们将通过将改进的血液损伤模型作为成本函数，并用实验数据验证建模假设，改进医疗设备的设计优化循环。这些信息将有助于开发一种针对患者的诊断数值工具，用于对患者特定血管（颈动脉和动脉硬化）进行彻底的实验和数值流调查。事实上，这种工具将改善预防、早期诊断和改善治疗以及预测血管和心血管疾病等严重健康状况的前景。