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Improved Delivery System for Drug-Coated Balloon Therapy

改进的药物涂层球囊治疗输送系统

基本信息

批准号：
10324442
负责人：
Nick Rydberg
金额：
$ 29.93万
依托单位：
MINNESOTA HEALTHSOLUTIONS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10324442
关键词：
Adverse event Affect Amputation Arterial Occlusive Diseases Arteries Atherosclerosis Balloon Angioplasty Balloon Dilatation Biomechanics Caliber Cardiovascular system Catheters Cause of Death Cessation of life Characteristics Cholesterol Chronic Collaborations Computer software Coronary Arteriosclerosis Cost Sharing Data Deposition Development Devices Diffuse Diffusion Disease Dissection Doctor of Philosophy Drug Delivery Systems Drug Kinetics Drug Transport Electrical Engineering Engineering Event Fiber Friction Funding Gangrene Hand Hospitals Incidence Intervention Investments Lead Lesion Limb structure Lower Extremity Mechanical Stress Mechanics Medical Meta-Analysis Microscopic Minnesota Modeling North America Oryctolagus cuniculus Paclitaxel Pain Penetration Periodicity Peripheral Peripheral arterial disease Persons Pharmaceutical Preparations Phase Physiologic pulse Privatization Property Pump R44 grant Recording of previous events Research Resources Scientist Solubility Specific qualifier value Stress Structure Surface Symptoms System Time Tissues Ulcer United States United States National Institutes of Health Vascular Diseases Vascular blood supply Woman antiproliferative agents antiproliferative drugs artery occlusion common treatment design design and construction drug efficacy experience hemodynamics improved improved outcome in vivo innovation instrumentation lipophilicity loss of function medical schools novel novel therapeutics product development prototype reduce symptoms repaired research and development response restenosis shear stress uptake

项目摘要

Project Summary/Abstract We propose to develop a novel angioplasty balloon inflation system to improve the efficacy of drug-coated balloon angioplasty. Atherosclerosis, characterized by the deposition of plaques of fatty material on the inner walls of arteries, can lead to the development of peripheral arterial disease (PAD) due to obstructive narrowing of arteries that supply blood to the extremities. PAD frequently causes a wide variety of ischemic symptoms including pain, non-healing arterial insufficiency ulcers, lower limb tissue loss and gangrene. Percutaneous drug-coated balloon angioplasty of PAD blockages has been observed to reduce symptoms, salvage affected limbs and prolong survival.

项目总结/摘要我们建议开发一种新的血管成形术球囊膨胀系统，以提高药物涂层的疗效。球囊血管成形术。动脉粥样硬化，特征是脂肪物质斑块沉积在血管内壁动脉壁，可导致阻塞性狭窄导致外周动脉疾病（PAD）的发展为四肢供血的动脉PAD经常引起各种缺血性症状包括疼痛、不愈合的动脉功能不全溃疡、下肢组织缺损和坏疽。经皮已观察到药物涂层球囊血管成形术治疗PAD阻塞可减轻症状，四肢和延长生存。