"Novel Acquisition Techniques, Contrast Mechanisms & Data Analysis Algorithms for Studying Regional Differences in fMRI Sensitivity"

“新颖的采集技术、对比机制

• 批准号: 288166-2012
• 负责人: Beyea, Steven
• 金额: $ 1.46万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571357
• 关键词: Novel; Acquisition; Techniques; Contrast; Mechanisms

2011 marks the twentieth anniversary of the first published research in human functional MRI (fMRI). Since that time many thousands of articles have been published describing and using fMRI, however, significant challenges remain. This research program aims to address some of these challenges by developing and optimizing new functional neuroimaging techniques that will provide advanced capabilities, as well as improving understanding of the biophysical mechanisms that generate image contrast. The driving hypothesis to this work is that high field imaging advances exist at the interface between physics and neuroscience. In particular, this program will explore techniques for functional mapping of brain regions with neuro-vascular/hemodynamic properties that differ from areas that are traditionally studied with fMRI (e.g. white matter, cortical structures near lesions etc). A sequential series of research projects will be used; starting with advanced MRI acquisition techniques, followed by developing and benchmarking data analysis methods, and then utilizing both these advances to improve our understanding of regional and global differences in fMRI sensitivity/specificity due to differing biophysical properties.

2011年是人类功能磁共振成像(FMRI)研究首次发表20周年。自那时以来，已经发表了数千篇描述和使用功能磁共振成像的文章，然而，巨大的挑战仍然存在。 这项研究计划旨在通过开发和优化新的功能神经成像技术来解决其中的一些挑战，这些技术将提供先进的功能，以及提高对产生图像对比度的生物物理机制的理解。这项工作的推动力假设是，高场成像的进步存在于物理学和神经科学的交界处。特别是，该计划将探索具有神经血管/血液动力学特性的大脑区域的功能映射技术，这些区域不同于传统的功能磁共振研究区域(例如，白质、病变附近的皮质结构等)。 将使用一系列连续的研究项目；从先进的磁共振成像获取技术开始，然后开发和基准数据分析方法，然后利用这两个进展来提高我们对不同生物物理属性导致的功能磁共振敏感性/特异性的地区和全球差异的理解。