Development of computational tools for patient-specific aortic valve repair simulation
开发用于患者特定主动脉瓣修复模拟的计算工具
基本信息
- 批准号:312065-2012
- 负责人:
- 金额:$ 1.89万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2015
- 资助国家:加拿大
- 起止时间:2015-01-01 至 2016-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The number of patients with aortic valve disease keeps growing due to the aging of the population in Canada and elsewhere. Aortic valve repair can mitigate the impact of aortic valve disease on quality of life and life expectancy. The proposed research program aims to allow more patients to benefit from aortic valve repair by providing the majority of cardiac surgeons who are not experts in this procedure with reliable simulation tools to help them choose between different aortic valve repair techniques in a patient-specific manner. This choice will be based on mechanistic aspects such as overall valve function, mechanical stress level in the valvular components (i.e. a predictor of risk of immediate tissue tearing and/or long-term calcification), opening and closing characteristics, and sealing quality of the valve. In addition, new methods will be developed to reduce computational time. An aortic valve repair expert cardiac surgeon and a trained anesthesiologist and echocardiographer from the University of Ottawa Heart Institute have committed their continued participation to provide medical expertise and patient data, thereby maximizing the clinical relevance of the research program. Given the clinical and financial advantages of aortic valve repair over replacement, this will greatly benefit the Canadian healthcare system.
由于加拿大和其他地方的人口老龄化,主动脉瓣疾病患者的数量不断增加。主动脉瓣修复术可以减轻主动脉瓣疾病对生活质量和预期寿命的影响。拟议的研究计划旨在通过为大多数不是该手术专家的心脏外科医生提供可靠的模拟工具,帮助他们以患者特定的方式选择不同的主动脉瓣修复技术,从而使更多患者从主动脉瓣修复中受益。该选择将基于机械方面,例如瓣膜的整体功能、瓣膜组件中的机械应力水平(即,即刻组织撕裂和/或长期钙化风险的预测因子)、打开和关闭特征以及瓣膜的密封质量。此外,还将开发新的方法来减少计算时间。来自渥太华大学心脏研究所的一名主动脉瓣修复专家心脏外科医生和一名训练有素的麻醉师和超声心动图技师承诺继续参与提供医学专业知识和患者数据,从而最大限度地提高研究项目的临床相关性。鉴于主动脉瓣修复术相对于置换术的临床和经济优势,这将极大地有利于加拿大的医疗保健系统。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Labrosse, Michel其他文献
Experimental Investigation of Left Ventricular Flow Patterns After Percutaneous Edge-to-Edge Mitral Valve Repair
- DOI:
10.1111/aor.13020 - 发表时间:
2018-05-01 - 期刊:
- 影响因子:2.4
- 作者:
Jeyhani, Morteza;Shahriari, Shahrokh;Labrosse, Michel - 通讯作者:
Labrosse, Michel
Labrosse, Michel的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Labrosse, Michel', 18)}}的其他基金
Experimental and computational investigation of mechanical function as influenced by shape and material properties in native and surgically modified heart valves
受天然和手术改良心脏瓣膜形状和材料特性影响的机械功能的实验和计算研究
- 批准号:
RGPIN-2017-04588 - 财政年份:2021
- 资助金额:
$ 1.89万 - 项目类别:
Discovery Grants Program - Individual
Experimental and computational investigation of mechanical function as influenced by shape and material properties in native and surgically modified heart valves
受天然和手术改良心脏瓣膜形状和材料特性影响的机械功能的实验和计算研究
- 批准号:
RGPIN-2017-04588 - 财政年份:2020
- 资助金额:
$ 1.89万 - 项目类别:
Discovery Grants Program - Individual
Experimental and computational investigation of mechanical function as influenced by shape and material properties in native and surgically modified heart valves
受天然和手术改良心脏瓣膜形状和材料特性影响的机械功能的实验和计算研究
- 批准号:
RGPIN-2017-04588 - 财政年份:2019
- 资助金额:
$ 1.89万 - 项目类别:
Discovery Grants Program - Individual
Experimental and computational investigation of mechanical function as influenced by shape and material properties in native and surgically modified heart valves
受天然和手术改良心脏瓣膜形状和材料特性影响的机械功能的实验和计算研究
- 批准号:
RGPIN-2017-04588 - 财政年份:2018
- 资助金额:
$ 1.89万 - 项目类别:
Discovery Grants Program - Individual
Experimental and computational investigation of mechanical function as influenced by shape and material properties in native and surgically modified heart valves
受天然和手术改良心脏瓣膜形状和材料特性影响的机械功能的实验和计算研究
- 批准号:
RGPIN-2017-04588 - 财政年份:2017
- 资助金额:
$ 1.89万 - 项目类别:
Discovery Grants Program - Individual
Understanding shear in anisotropic materials for enhances sample attachment strategy
了解各向异性材料中的剪切以增强样品附着策略
- 批准号:
494081-2016 - 财政年份:2016
- 资助金额:
$ 1.89万 - 项目类别:
Engage Grants Program
Partnering toward a left-heart simulator based on a passively beating porcine heart
合作开发基于被动跳动猪心脏的左心模拟器
- 批准号:
485778-2015 - 财政年份:2015
- 资助金额:
$ 1.89万 - 项目类别:
Interaction Grants Program
Design, manufacturing and testing of a left-heart simulator based on a passively beating porcine heart and compatible with ViVitro's Pulse Duplicator system
基于被动跳动的猪心脏并与 ViVitro 的脉冲复制器系统兼容的左心模拟器的设计、制造和测试
- 批准号:
484328-2015 - 财政年份:2015
- 资助金额:
$ 1.89万 - 项目类别:
Engage Grants Program
Development of computational tools for patient-specific aortic valve repair simulation
开发用于患者特定主动脉瓣修复模拟的计算工具
- 批准号:
312065-2012 - 财政年份:2014
- 资助金额:
$ 1.89万 - 项目类别:
Discovery Grants Program - Individual
Development of computational tools for patient-specific aortic valve repair simulation
开发用于患者特定主动脉瓣修复模拟的计算工具
- 批准号:
312065-2012 - 财政年份:2013
- 资助金额:
$ 1.89万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
物体运动对流场扰动的数学模型研究
- 批准号:51072241
- 批准年份:2010
- 资助金额:10.0 万元
- 项目类别:专项基金项目
Computational Methods for Analyzing Toponome Data
- 批准号:60601030
- 批准年份:2006
- 资助金额:17.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Computational Infrastructure for Automated Force Field Development and Optimization
用于自动力场开发和优化的计算基础设施
- 批准号:
10699200 - 财政年份:2023
- 资助金额:
$ 1.89万 - 项目类别:
Open-source Software Development Supplement for 3D quantitative analysisof mouse models of structural birth defects through computational anatomy
通过计算解剖学对结构性出生缺陷小鼠模型进行 3D 定量分析的开源软件开发补充
- 批准号:
10839199 - 财政年份:2023
- 资助金额:
$ 1.89万 - 项目类别:
Development of data driven and AI empowered systems biology to study human diseases
数据驱动和人工智能的发展使系统生物学能够研究人类疾病
- 批准号:
10714763 - 财政年份:2023
- 资助金额:
$ 1.89万 - 项目类别:
Development of SUMO1 small molecule degraders as the first-in-class anticancerdrugs for metastatic colorectal cancer
开发 SUMO1 小分子降解剂作为治疗转移性结直肠癌的一流抗癌药物
- 批准号:
10484074 - 财政年份:2022
- 资助金额:
$ 1.89万 - 项目类别:
A novel platform to enhance single cell interrogation of nervous system development
增强神经系统发育单细胞询问的新平台
- 批准号:
10678917 - 财政年份:2022
- 资助金额:
$ 1.89万 - 项目类别:
Development of SUMO1 small molecule degraders as the first-in-class anticancerdrugs for metastatic colorectal cancer
开发 SUMO1 小分子降解剂作为治疗转移性结直肠癌的一流抗癌药物
- 批准号:
10651880 - 财政年份:2022
- 资助金额:
$ 1.89万 - 项目类别:
DMS/NIGMS 1: Collaborative Research: Advanced Ion Channel Modeling and Computational Tools with Application to Voltage-Dependent Anion Channel and Mitochondrial Model Development
DMS/NIGMS 1:合作研究:先进离子通道建模和计算工具,应用于电压依赖性阴离子通道和线粒体模型开发
- 批准号:
2153387 - 财政年份:2022
- 资助金额:
$ 1.89万 - 项目类别:
Standard Grant
Continuous longitudinal atlas construction for the study of brain development
用于大脑发育研究的连续纵向图谱构建
- 批准号:
10683307 - 财政年份:2022
- 资助金额:
$ 1.89万 - 项目类别:
Investigate MOF regulated epigenetic mechanisms of skin development
研究 MOF 调节皮肤发育的表观遗传机制
- 批准号:
10467552 - 财政年份:2022
- 资助金额:
$ 1.89万 - 项目类别:
Development of computational tools for accounting for host variability in predicting T-cell epitopes
开发计算工具来解释预测 T 细胞表位时的宿主变异性
- 批准号:
10502033 - 财政年份:2022
- 资助金额:
$ 1.89万 - 项目类别: