X-Ray Optics for Synchrotron Biomedical Imaging Research

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As principal investigator and team leader, Prof. Chapman has led the design, specification, construction, and initial operations of the world-leading BioMedical Imaging and Therapy (BMIT) facility at the Canadian Light Source (CLS). BMIT is now among the global leaders in human and animal health research using synchrotron radiation. In parallel with personally guiding the development of this uniquely Canadian resource, he has developed extensive biomedical and clinical collaborations enabling new research from cancer detection to bone health to gene expression imaging. These collaborations and his continued development and application of advanced imaging technologies provide a rich multidisciplinary environment for training of HQP. He and collaborators have used synchrotron facilities to develop and commercialize imaging technologies for pre-clinical applications, including novel studies of genetics, stroke, and heart attack. He proposes to continue a program of developing new imaging technologies in support of the biomedical programs. In this application he proposes to investigate and further develop imaging beams for larger objects using unique x-ray optics. This would expand, with minimal cost, the capabilities of the BMIT beamline for imaging large animals or humans and thus greatly enhancing BMIT capabilities by enabling a new class of subjects that can be investigated. He also proposes developing a new approach to imaging optics within a beamline that matches cost effective purpose built optics to a specific imaging application akin to lenses for a SLR camera, further expanding the utility of the BMIT facility for the user community. These projects are part of a program to develop new methods of synchrotron imaging, push the limits of existing synchrotron imaging methods, apply synchrotron imaging methods to biomedical systems, and translate synchrotron imaging methods to the laboratory or pre-clinical health research environment.