X-Ray Optics for Synchrotron Biomedical Imaging Research

作为首席研究员和团队负责人，Chapman教授领导了加拿大光源（CLS）世界领先的生物医学成像和治疗（BMIT）设施的设计，规范，建设和初步运营。BMIT现在是使用同步辐射进行人类和动物健康研究的全球领导者之一。在亲自指导这一独特的加拿大资源的开发的同时，他还开展了广泛的生物医学和临床合作，使从癌症检测到骨骼健康再到基因表达成像的新研究成为可能。这些合作以及他对先进成像技术的持续开发和应用为HQP的培训提供了丰富的多学科环境。他和合作者利用同步加速器设施开发和商业化临床前应用的成像技术，包括遗传学，中风和心脏病发作的新研究。 他建议继续开发新的成像技术，以支持生物医学项目。 在这一应用中，他提出研究并进一步开发使用独特的X射线光学器件用于较大物体的成像光束。 这将以最小的成本扩大BMIT光束线对大型动物或人类成像的能力，从而通过实现可以研究的一类新的受试者而大大增强BMIT能力。 他还建议开发一种新的方法来在光束线内成像光学器件，该方法将具有成本效益的专用光学器件与类似于单反相机镜头的特定成像应用相匹配，进一步扩展了BMIT设施对用户社区的实用性。 这些项目是开发同步辐射成像新方法的计划的一部分，推动现有同步辐射成像方法的极限，将同步辐射成像方法应用于生物医学系统，并将同步辐射成像方法转化为实验室或临床前健康研究环境。

As principal investigator and team leader, Prof. Chapman has led the design, specification, construction, and initial operations of the world-leading BioMedical Imaging and Therapy (BMIT) facility at the Canadian Light Source (CLS). BMIT is now among the global leaders in human and animal health research using synchrotron radiation. In parallel with personally guiding the development of this uniquely Canadian resource, he has developed extensive biomedical and clinical collaborations enabling new research from cancer detection to bone health to gene expression imaging. These collaborations and his continued development and application of advanced imaging technologies provide a rich multidisciplinary environment for training of HQP. He and collaborators have used synchrotron facilities to develop and commercialize imaging technologies for pre-clinical applications, including novel studies of genetics, stroke, and heart attack. He proposes to continue a program of developing new imaging technologies in support of the biomedical programs. In this application he proposes to investigate and further develop imaging beams for larger objects using unique x-ray optics. This would expand, with minimal cost, the capabilities of the BMIT beamline for imaging large animals or humans and thus greatly enhancing BMIT capabilities by enabling a new class of subjects that can be investigated. He also proposes developing a new approach to imaging optics within a beamline that matches cost effective purpose built optics to a specific imaging application akin to lenses for a SLR camera, further expanding the utility of the BMIT facility for the user community. These projects are part of a program to develop new methods of synchrotron imaging, push the limits of existing synchrotron imaging methods, apply synchrotron imaging methods to biomedical systems, and translate synchrotron imaging methods to the laboratory or pre-clinical health research environment.