Using drosophila to discern cell death signaling pathways

利用果蝇辨别细胞死亡信号通路

• 批准号: 411453-2011
• 负责人: Barker, Philip
• 金额: $ 4.08万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=573424
• 关键词: Using; drosophila; discern; cell; death

Every day, about 100,000,000 cells in our bodies commit suicide. This process, termed apoptosis, is used to remove old dysfunctional cell, to terminate active immune responses, and to prevent the growth of precancerous cells. Apoptosis is crucial for our health and is therefore very tightly controlled. However, this system is not perfect and too much or too little apoptosis is major factor in neurodegenerative conditions such as ALS and Parkinson's disease and in a wide array of human cancers. Apoptosis is important not only for humans but plays crucial roles in the development of almost all multi-cellular organisms. In fact, the emergence of this intrinsic cellular suicide program in our ancient ancestors was almost certainly a critical evolutionary event that allowed complex multicellular organisms to develop and flourish. Indeed, the mechanisms that regulate apoptosis are very similar in diverse species, including the fruit fly Drosophila melanogaster. Detailed genetic studies that can reveal the mechanisms of apoptosis in Drosophila melanogastercan be done quickly and at low cost. With the NSERC discovery grant funding, we will develop a new program that will combine the power of Drosophila genetics with our established strengths in biochemistry and molecular biology to gain new insights into cell suicide pathways that are conserved from flies to man.

每天，我们体内大约有100，000，000个细胞自杀。这一过程被称为细胞凋亡， 去除旧的功能失调的细胞，终止活跃的免疫反应，并防止生长 癌前细胞细胞凋亡对我们的健康至关重要，因此受到严格控制。但这 系统并不完美，过多或过少的细胞凋亡是神经退行性疾病的主要因素， 如肌萎缩侧索硬化症和帕金森氏症以及一系列人类癌症。 细胞凋亡不仅对人类很重要，而且在几乎所有的发育过程中都起着至关重要的作用。 多细胞有机体。事实上，这种内在的细胞自杀程序的出现， 几乎可以肯定，祖先是一个关键的进化事件，使复杂的多细胞生物， 发展和繁荣。事实上，调节细胞凋亡的机制在不同物种中非常相似， 包括果蝇Drosophila melanogaster。 详细的遗传学研究可以揭示果蝇细胞凋亡的机制 快速和低成本。有了NSERC发现补助金的资助，我们将开发一个新的计划， 联合收割机将果蝇遗传学的力量与我们在生物化学和分子生物学方面的优势结合起来， 生物学获得新的见解细胞自杀途径是保守的从苍蝇到人。