Neuromuscular mechanisms governing knee joint biomechanics during normal gait

正常步态下控制膝关节生物力学的神经肌肉机制

• 批准号: 418025-2013
• 负责人: Hunt, Michael
• 金额: $ 2.11万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=573488
• 关键词: Neuromuscular; mechanisms; governing; knee; joint

During ambulation, the joints of the lower limb - the knee in particular - must withstand large forces exerted onto them to permit the smooth and efficient continuation of forward progression. While structures such as bones and ligaments can assist in the distribution of these forces, our muscles are believed to be primarily responsible for absorption of these forces and to protect the joints over time. Previous researchers have attempted to model the distribution of forces throughout the knee joint during walking, though these models are limited in their accuracy due to a lack of information regarding the anatomy of the lower limb during weight-bearing activities and the difficulty in isolating the effects of muscle activation on movement parameters. The proposed mechanistic research program will provide new information about not only the relationships between aspects of muscle function and loading at the knee joint during walking, but the neuromuscular control of normal human movement. We will investigate the relationships between measures of knee joint loading and neuromuscular outcomes such as output from the brain, muscle power, and the relative timing of different lower limb muscles. We will also combine images of knee joint structure during weight-bearing to produce a more accurate model of the complex relationship between muscle and joints during movement. This proposed research will provide an integrated analysis of neuromuscular function from the brain, through the nerves, and out to the muscles which will act as a new model for neuromuscular assessment of physical function. It will provide evidence on the effects of diminished muscle function which will not only serve as a basis for future applied research, but will help to refine current models of normal movement. Finally, this basic research on normal function may be used by future researchers to develop optimal treatment strategies for people with diminished muscle and joint function.

在截肢过程中，下肢的关节-特别是膝关节-必须承受施加在它们上的巨大力量，以允许平稳有效地继续向前推进。虽然骨骼和韧带等结构可以帮助分配这些力，但我们的肌肉被认为主要负责吸收这些力并随着时间的推移保护关节。以前的研究人员曾试图模拟步行过程中整个膝关节的力分布，但由于缺乏有关负重活动期间下肢解剖结构的信息以及难以隔离肌肉激活对运动参数的影响，这些模型的准确性有限。拟议的机械研究计划将提供新的信息，不仅在步行过程中的肌肉功能和膝关节负荷方面的关系，但正常人体运动的神经肌肉控制。 我们将研究膝关节负荷的测量和神经肌肉结果之间的关系，例如大脑的输出，肌肉力量和不同下肢肌肉的相对时间。我们还将结合负重时膝关节结构的联合收割机图像，以产生运动过程中肌肉和关节之间复杂关系的更精确模型。这项拟议的研究将提供从大脑到神经再到肌肉的神经肌肉功能的综合分析，这将成为身体功能神经肌肉评估的新模型。它将为肌肉功能减弱的影响提供证据，这不仅将作为未来应用研究的基础，而且将有助于完善目前的正常运动模型。最后，这项关于正常功能的基础研究可能会被未来的研究人员用来为肌肉和关节功能减弱的人制定最佳治疗策略。