IMPLANTABLE MICRO-DEVICE to MONITOR MUSCLE COMPARTMENT PRESSURE in TRAUMA VICTIMS

用于监测创伤患者肌肉室压力的植入式微型设备

• 批准号: 462278-2014
• 负责人: Harvey, Edward
• 金额: $ 5.51万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=576859
• 关键词: IMPLANTABLE; MICRO; DEVICE; MONITOR; MUSCLE

In human limbs the muscles are bundled into compartments surrounded by inelastic tissue called fascia. High energy impact to muscles, such as that sustained during an accident, results in swelling of the damaged tissue. This raises the tissue pressure and results in the condition called Acute Compartment Syndrome (ACS). The confining fascia must be cut to release pressure once it rises to a critical level or the patient will experience severe intractable pain and disability as a result of permanent muscle damage. There is no existing technology capable of measuring muscle compartment pressure accurately and on a continuous basis. The goal of this project is to develop a simple, miniature, wireless device that can be used by first responders in the field or in an emergency department to measure pressure, oxygen and temperature fluctuations in the muscle compartments of patients at risk of ACS. The proposed device measuring 4 mm x 23 mm will be delivered to the compartment with a modified syringe and will have a tail that protrudes from the skin to facilitate removal 48 hours post injury. The sensor will undergo pre-clinical assessment in established models of compartment syndrome, including live animal and human cadaveric models. The intellectual property for the device is protected by an agreement with McGill University and a working agreement has been signed with the technology user, Sharp Microsystems. The medical device lobby group MEDEC has also been engaged for eventual dispersal. We believe this device will revolutionize the management of trauma victims in every hospital throughout the world and minimize the devastating outcomes for patients diagnosed with ACS.

在人类四肢中，肌肉被捆绑成被称为筋膜的无弹性组织包围的隔室。高能量冲击 例如在事故中受到的伤害，导致受损组织肿胀。这会使组织 压力和结果的条件称为急性昏迷综合征（ACS）。必须切割围带， 一旦压力上升到临界水平，则释放压力，否则患者将因此经历严重的顽固性疼痛和残疾 永久性肌肉损伤没有能够测量肌肉室压力的现有技术 准确和持续的基础上。这个项目的目标是开发一个简单的，微型的，无线设备，可以 用于现场或急诊室的急救人员测量压力、氧气和温度 ACS风险患者的肌肉间室波动。拟议的4 mm x 23 mm器械将 并且具有从皮肤突出以便于移除的尾部48 受伤后的几个小时传感器将在已建立的筋膜室综合征模型中进行临床前评估， 包括活体动物和人类尸体模型。该器械的知识产权受以下协议的保护： 麦吉尔大学和工作协议已签署的技术用户，夏普微系统。医疗 设备游说团体MEDEC也参与了最终的分散。我们相信这个装置将彻底改变 在世界各地每家医院管理创伤受害者，并最大限度地减少患者的毁灭性后果 被诊断为ACS。