Developing an integrated method of preparing bioactive peptides from spent hens for functional food/nutraceutical and cosmetic applications

每年，加拿大蛋业中大约有2250万只蛋鸡在其产蛋周期结束时被“消耗”，需要从生产中移除。废鸡对农民来说没有什么经济价值，被视为副产品或废物。处置废鸡往往是生产者的责任，他们必须支付相关的运输和处置费用。寻找产生剩余价值的新用途对蛋品工业来说意义重大。该项目的总体目标是开发一种从废母鸡中制备功能性食品/营养保健品和化妆品应用的生物活性肽的综合方法。降压肽将首先由废鸡肌肉蛋白制备，然后剩余的胶原材料将用于制备胶原蛋白肽。降压肽的作用将在自发性高血压大鼠身上进行研究，这是一种与人类高血压相似的高血压实验模型。大约22%的加拿大成年人和80%的65岁以上的加拿大人患有高血压。该项目的研究结果将导致新的降压肽产品，对高血压有益。皮肤作为人体最大的可观察器官，其可见外观在人类社会交往中起着重要作用。从废母鸡中制备的胶原蛋白肽具有抗氧化应激和炎症的活性，同时增强细胞增殖和细胞外基质合成（如胶原蛋白和弹性蛋白），可能为改善皮肤健康提供新的方法。从废母鸡中开发生物活性肽，对高血压和皮肤健康有益，将为加拿大蛋业提供一种可持续的替代丢弃废母鸡尸体的方法。除了为蛋业创造新的收入来源外，增值废母鸡加工的盈利部分也将有助于消除与废母鸡处理相关的环境影响，从而增强蛋业作为环境管家的积极形象。

Every year, approximate 22.5 million laying hens in the Canadian egg industry become "spent" at the conclusion of their laying cycle that need to be removed from production. Spent hens are of little economic value to the farmers and seen as a by-product or a waste. Disposal of spent hens often is a liability for the producers who have to pay the associated cost of transportation and disposal. Finding new uses to yield residual value is significant to the egg industry. The overarching objective of this project is to develop an integrated method of preparing bioactive peptides from spent hens for functional food/nutraceutical and cosmetic applications. Antihypertensive peptides will be first prepared from spent hen muscle proteins and then the leftover collagenous material will be used for preparing collagen peptides. Efficacy of antihypertensive peptides will be studied in spontaneously hypertensive rats, an experimental model for hypertension with similarities for hypertension in humans. Hypertension afflicts ~22% of Canadian adults and 80% of the Canadian population over the age of 65. Findings from the project will lead to novel antihypertensive peptide products with benefits against hypertension. As the body's largest observable organ, skin's visible appearance plays an important role in human social interactions. Collagen peptides prepared from spent hen with demonstrated activities against oxidative stress and inflammation while enhanced cell proliferation and extracellular matrix synthesis (such as collagen and elastin) may offer novel approaches to improve skin health in cosmetic applications. Developing bioactive peptides from spent hen with beneficial effects on hypertension and skin health will provide the Canadian egg industry with a sustainable alternative to discarding spent hen carcasses. In addition to generating a new revenue source for the egg industry, a profitable section of value-added spent hen processing will also help eliminate environment impact associated with spent hen disposal, and thus enhance the positive image of the egg industry as environmental stewards.