Developing an integrated method of preparing bioactive peptides from spent hens for functional food/nutraceutical and cosmetic applications

开发一种从废母鸡中制备生物活性肽的综合方法，用于功能性食品/营养保健品和化妆品应用

• 批准号: 477022-2014
• 负责人: Wu, Jianping
• 金额: $ 2.44万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=578792
• 关键词: Developing; integrated; method; preparing; bioactive

Every year, approximate 22.5 million laying hens in the Canadian egg industry become "spent" at the conclusion of their laying cycle that need to be removed from production. Spent hens are of little economic value to the farmers and seen as a by-product or a waste. Disposal of spent hens often is a liability for the producers who have to pay the associated cost of transportation and disposal. Finding new uses to yield residual value is significant to the egg industry. The overarching objective of this project is to develop an integrated method of preparing bioactive peptides from spent hens for functional food/nutraceutical and cosmetic applications. Antihypertensive peptides will be first prepared from spent hen muscle proteins and then the leftover collagenous material will be used for preparing collagen peptides. Efficacy of antihypertensive peptides will be studied in spontaneously hypertensive rats, an experimental model for hypertension with similarities for hypertension in humans. Hypertension afflicts ~22% of Canadian adults and 80% of the Canadian population over the age of 65. Findings from the project will lead to novel antihypertensive peptide products with benefits against hypertension. As the body's largest observable organ, skin's visible appearance plays an important role in human social interactions. Collagen peptides prepared from spent hen with demonstrated activities against oxidative stress and inflammation while enhanced cell proliferation and extracellular matrix synthesis (such as collagen and elastin) may offer novel approaches to improve skin health in cosmetic applications. Developing bioactive peptides from spent hen with beneficial effects on hypertension and skin health will provide the Canadian egg industry with a sustainable alternative to discarding spent hen carcasses. In addition to generating a new revenue source for the egg industry, a profitable section of value-added spent hen processing will also help eliminate environment impact associated with spent hen disposal, and thus enhance the positive image of the egg industry as environmental stewards.

每年，加拿大鸡蛋行业约有2250万只蛋鸡在产蛋周期结束时“消耗”，需要从生产中淘汰。废母鸡对农民来说没有什么经济价值，被视为副产品或废物。处理废母鸡往往是生产者的责任，他们必须支付运输和处理的相关费用。寻找新的用途以产生剩余价值对鸡蛋行业具有重要意义。该项目的总体目标是开发一种从废母鸡中制备生物活性肽的综合方法，用于功能性食品/营养品和化妆品应用。首先从废鸡肌肉蛋白中制备降血压肽，然后将剩余的胶原材料用于制备胶原肽。将在自发性高血压大鼠中研究抗高血压肽的功效，自发性高血压大鼠是与人类高血压相似的高血压实验模型。高血压困扰着约22%的加拿大成年人和80%的65岁以上的加拿大人口。该项目的发现将导致新的抗高血压肽产品对高血压的好处。作为人体最大的可观察器官，皮肤的可见外观在人类社会交往中起着重要作用。从废母鸡制备的胶原蛋白肽具有抗氧化应激和炎症的活性，同时增强细胞增殖和细胞外基质合成（如胶原蛋白和弹性蛋白），可以提供在化妆品应用中改善皮肤健康的新方法。从废母鸡中开发对高血压和皮肤健康有益的生物活性肽将为加拿大鸡蛋行业提供一种可持续的替代方法，以丢弃废母鸡尸体。除了为蛋品行业创造新的收入来源外，高附加值的废母鸡加工的盈利部分还将有助于消除与废母鸡处置相关的环境影响，从而提高蛋品行业作为环境管理者的积极形象。